Hai Tsonwin, Wolford Christopher C, Chang Yi-Seok
Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH, USA.
Gene Expr. 2010;15(1):1-11. doi: 10.3727/105221610x12819686555015.
Activating transcription factor 3 (ATF3) gene encodes a member of the ATF family of transcription factors and is induced by various stress signals. All members of this family share the basic region-leucine zipper (bZip) DNA binding motif and bind to the consensus sequence TGACGTCA in vitro. Previous reviews and an Internet source have covered the following topics: the nomenclature of ATF proteins, the history of their discovery, the potential interplays between ATFs and other bZip proteins, ATF3-interacting proteins, ATF3 target genes, and the emerging roles of ATF3 in cancer and immunity (see footnote 1). In this review, we present evidence and clues that prompted us to put forth the idea that ATF3 functions as a "hub" of the cellular adaptive-response network. We will then focus on the roles of ATF3 in modulating inflammatory response. Inflammation is increasingly recognized to play an important role for the development of many diseases. Putting this in the context of the hub idea, we propose that modulation of inflammation by ATF3 is a unifying theme for the potential involvement of ATF3 in various diseases.
激活转录因子3（ATF3）基因编码转录因子ATF家族的一个成员，并且受多种应激信号诱导。该家族的所有成员都共享基本区域-亮氨酸拉链（bZip）DNA结合基序，并在体外与共有序列TGACGTCA结合。先前的综述和一个互联网资源已经涵盖了以下主题：ATF蛋白的命名、它们的发现历史、ATF与其他bZip蛋白之间潜在的相互作用、与ATF3相互作用的蛋白、ATF3的靶基因，以及ATF3在癌症和免疫中的新作用（见脚注1）。在本综述中，我们展示了促使我们提出ATF3作为细胞适应性反应网络的“枢纽”这一观点的证据和线索。然后我们将聚焦于ATF3在调节炎症反应中的作用。炎症在许多疾病的发展中所起的重要作用日益受到认可。将其置于枢纽观点的背景下，我们提出ATF3对炎症的调节是ATF3可能参与各种疾病的一个统一主题。
