XBP1的新作用，一种超级转录因子。
Emerging roles for XBP1, a sUPeR transcription factor.
作者信息
He Yin, Sun Shengyi, Sha Haibo, Liu Ziying, Yang Liu, Xue Zhen, Chen Hui, Qi Ling
机构信息
Graduate Program in Genetics and Development, Cornell University, Ithaca, NY 14853, USA.
出版信息
Gene Expr. 2010;15(1):13-25. doi: 10.3727/105221610x12819686555051.
Abstract
X-box binding protein 1 (XBP1) is a unique basic region leucine zipper (bZIP) transcription factor whose active form is generated by a nonconventional splicing reaction upon disruption of homeostasis in the endoplasmic reticulum (ER) and activation of the unfolded protein response (UPR). XBP1, first identified as a key regulator of major histocompatibility complex (MHC) class II gene expression in B cells, represents the most conserved signaling component of UPR and is critical for cell fate determination in response to ER stress. Here we review recent advances in our understanding of this multifaceted transcription factor in health and diseases.
摘要
X盒结合蛋白1（XBP1）是一种独特的碱性区域亮氨酸拉链（bZIP）转录因子，其活性形式是在内质网（ER）稳态破坏和未折叠蛋白反应（UPR）激活时通过非常规剪接反应产生的。XBP1最初被鉴定为B细胞中主要组织相容性复合体（MHC）II类基因表达的关键调节因子，是UPR中最保守的信号成分，对于细胞应对内质网应激时的命运决定至关重要。在此，我们综述了对这种多面转录因子在健康和疾病方面理解的最新进展。
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