Department of Animal Biology, University of Pennsylvania Veterinary School, Philadelphia, Pennsylvania, USA.
Ann N Y Acad Sci. 2010 Nov;1211:3-8. doi: 10.1111/j.1749-6632.2010.05811.x.
This review explores advances in our understanding of dynamicism in cellular signaling. Areas highlighted include the role of stochasticity in producing diversity in analogous signaling circumstances; population desynchronization's effect in masking newly appreciated repetitive bursts in protein phosphorylation and messenger RNA production; double-positive feedback interactions and their ability to synchronize multiple signal transduction pathways; scaffolding proteins control over signaling feedback; and frequency-responsive transcriptional regulation as an example of dynamicism in signaling.
这篇综述探讨了我们对细胞信号转导动态性理解的进展。重点介绍的领域包括随机性在类似信号环境中产生多样性的作用；群体去同步化对新出现的蛋白质磷酸化和信使 RNA 产生重复爆发的影响；双正反馈相互作用及其同步多个信号转导途径的能力；支架蛋白对信号反馈的控制；以及频率响应转录调节作为信号动态性的一个例子。
