Institute of Health Sciences, University of Opole, 68 Katowicka St., 45-060 Opole, Poland.
Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie St., 50-383 Wrocław, Poland.
Biomolecules. 2020 Oct 7;10(10):1417. doi: 10.3390/biom10101417.
This review focuses on the current knowledge on the involvement of metal ions in signaling processes within the cell, in both physiological and pathological conditions. The first section is devoted to the recent discoveries on magnesium and calcium-dependent signal transduction-the most recognized signaling agents among metals. The following sections then describe signaling pathways where zinc, copper, and iron play a key role. There are many systems in which changes in intra- and extra-cellular zinc and copper concentrations have been linked to important downstream events, especially in nervous signal transduction. Iron signaling is mostly related with its homeostasis. However, it is also involved in a recently discovered type of programmed cell death, ferroptosis. The important differences in metal ion signaling, and its disease-leading alterations, are also discussed.
这篇综述专注于当前关于金属离子在细胞内信号转导过程中的作用的知识，包括生理和病理条件下的作用。第一部分专门讨论了镁和钙依赖的信号转导的最新发现——这是金属中最被认可的信号转导物质。接下来的部分描述了锌、铜和铁发挥关键作用的信号通路。在许多系统中，细胞内外锌和铜浓度的变化与重要的下游事件相关，尤其是在神经信号转导中。铁信号主要与其稳态相关。然而，它也与最近发现的一种程序性细胞死亡方式——铁死亡有关。还讨论了金属离子信号转导的重要差异及其导致疾病的改变。
