Department of Animal Medicine and Surgery, Veterinary Faculty, University of Córdoba, Córdoba, Spain.
Vet Comp Oncol. 2010 Dec;8(4):254-62. doi: 10.1111/j.1476-5829.2010.00219.x.
Gliomatosis cerebri (GC) is a rare, diffusely infiltrating, glial cell tumour of neuroepithelial origin. This report describes a case of oligodendroglial GC in a 6-year-old male Poodle with central nervous system symptoms. Computed tomography revealed anomalous parenchyma density and ventricular asymmetry. Cerebrospinal fluid showed elevated protein (30 mg dL(-1)) and nucleated cell count (20 µL(-1)). Presumptive diagnosis of necrotizing meningoencephalitis was made. Because of rapid deterioration of the general condition of the animal, the dog was euthanized. Histologically there was an infiltration of round or ovoid neoplastic cells in the white matter of the left cerebral hemisphere and in leptomeninges. Immunohistochemistry showed that 80% of the neoplastic cells expressed Olig2 and some 50% expressed glial fibrilary acidic protein. On the basis of clinical, histological and immunohistochemical features, a diagnosis of oligodendoglial GC was done. This case represents the first report of a case of oligodendroglial GC in the canid.
脑胶质瘤病（GC）是一种罕见的、弥漫浸润性的神经上皮来源的胶质细胞瘤。本报告描述了一例 6 岁雄性贵宾犬患少突胶质细胞 GC 合并中枢神经系统症状。计算机断层扫描显示脑实质密度异常和脑室不对称。脑脊液显示蛋白（30mg/dL(-1)）和有核细胞计数（20µL(-1)）升高。初步诊断为坏死性脑膜脑炎。由于动物的一般状况迅速恶化，狗被安乐死。组织学上，左大脑半球白质和软脑膜中有圆形或卵圆形的肿瘤细胞浸润。免疫组织化学显示 80%的肿瘤细胞表达 Olig2，约 50%表达神经胶质纤维酸性蛋白。基于临床、组织学和免疫组织化学特征，做出了少突胶质细胞瘤的诊断。该病例代表了犬中首例少突胶质细胞瘤的报告。
