Porter B, de Lahunta A, Summers B
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Vet Pathol. 2003 Jan;40(1):97-102. doi: 10.1354/vp.40-1-97.
Gliomatosis cerebri is a well-recognized entity in human medicine characterized by unusually widespread infiltration of the neuraxis by neoplastic glial cells with relative preservation of brain architecture. This report describes the pathologic features of the disease in six dogs. The dogs ranged from 3 to 9 years of age (mean 6.1 years) without evidence of breed predilection; five of the six dogs were neutered or intact males. The clinical findings were mixed (including depression, circling, cranial nerve deficits), reflecting the diffuse nature of the disease. Histologically, there was remarkably diffuse infiltration of the white and gray matter of the brain by small numbers of elongated neoplastic cells. Areas of greater cellularity formed grossly visible lesions in four cases. Anisocytosis and pleomorphism were greater in areas of higher cellularity. Other features of tumor growth included subpial accumulation, neuronal satellitosis, perivascular cuffing, and tropism for cranial nerve and brain stem nuclei. Neoplastic cells were negative on immunohistochemical stains for glial fibrillary acid protein (GFAP) and leukocyte markers, reflecting the uncertain histogenesis of these unusual neoplasms.
大脑胶质瘤病是人类医学中一种公认的疾病实体，其特征是肿瘤性胶质细胞异常广泛地浸润神经轴，而脑结构相对保留。本报告描述了6只犬该疾病的病理特征。这些犬年龄在3至9岁之间（平均6.1岁），无品种易感性证据；6只犬中有5只为去势或未去势的雄性。临床症状多样（包括抑郁、转圈、颅神经功能缺损），反映了该疾病的弥漫性。组织学上，少量细长的肿瘤细胞显著弥漫性浸润脑白质和灰质。在4例中，细胞增多区域形成了肉眼可见的病变。细胞增多区域的细胞大小不均和异形性更大。肿瘤生长的其他特征包括软脑膜下积聚、神经元卫星现象、血管周围套袖样浸润以及对颅神经和脑干核的嗜性。肿瘤细胞对胶质纤维酸性蛋白（GFAP）和白细胞标志物的免疫组织化学染色呈阴性，反映了这些不寻常肿瘤的组织发生尚不确定。
