Department of Neurology and Clinical Neurophysiology, University Hospital of North Norway, Tromsø, Norway.
J Hypertens. 2011 Jan;29(1):36-42. doi: 10.1097/HJH.0b013e32834068e0.
In the vast majority of cases the cause for hypertension is not known. On the basis of observations from black and multiethnic populations, it has been hypothesized that a genetically high tissue creatine kinase activity may be an independent factor responsible for primary hypertension. If the relation between creatine kinase and blood pressure is causal, it is reasonable to believe that it will be independent of ethnicity and present in different populations. In this cross-sectional study, we examined whether creatine kinase was associated with blood pressure in a large Caucasian normal population.
Data on creatine kinase and blood pressure were analyzed in a random sample of 12 776 men and women (65% of those eligible), aged 30-87 years from a normal population in the municipality of Tromsø, Norway. We used linear regression to model the association between creatine kinase and blood pressure. Creatine kinase was independently associated with blood pressure. A one unit increase in log CK was associated with a 3.3 (95% CI 1.4-5.2) mmHg increase in systolic blood pressure and a 1.3 (95% CI 0.3-2.3) mmHg increase in diastolic blood pressure, after adjustment for age, sex, body mass index, s-glucose, s-creatinine, physical activity and alcohol consumption. The creatine kinase effect on blood pressure was independent of antihypertensive medication, and no difference in creatine kinase level was found between those with controlled and uncontrolled hypertension (geometric mean 101 vs. 104 IU/l, P = 0.1).
Creatine kinase was associated with blood pressure in this population.
绝大多数情况下，高血压的病因不明。基于黑人和多种族人群的观察结果，有人假设组织肌酸激酶活性高可能是原发性高血压的一个独立因素。如果肌酸激酶与血压之间的关系是因果关系，那么可以合理地认为这种关系不受种族影响，并存在于不同人群中。在这项横断面研究中，我们检验了肌酸激酶是否与一个大型白种人正常人群的血压有关。
我们分析了来自挪威特罗姆瑟市一个正常人群中随机抽取的 12776 名年龄在 30-87 岁的男性和女性（符合条件者的 65%）的肌酸激酶和血压数据。我们使用线性回归来建立肌酸激酶与血压之间的关联模型。肌酸激酶与血压独立相关。在调整年龄、性别、体重指数、空腹血糖、血清肌酐、体力活动和饮酒量后，logCK 每增加一个单位，收缩压增加 3.3mmHg（95%CI 1.4-5.2），舒张压增加 1.3mmHg（95%CI 0.3-2.3）。肌酸激酶对血压的影响独立于降压药物，且血压得到控制和未得到控制的高血压患者之间的肌酸激酶水平无差异（几何均数分别为 101 和 104IU/l，P=0.1）。
在该人群中，肌酸激酶与血压有关。
