基于手动和计算机辅助方法的乳腺 MRI 无肿块效应病变的动力学分析。

Kinetic analysis of lesions without mass effect on breast MRI using manual and computer-assisted methods.

机构信息

Department of Radiology, Klinikum Rechts der Isar, Technical University Munich, Ismaninger Strasse 22, 81675 Munich, Germany.

出版信息

Eur Radiol. 2011 May;21(5):893-8. doi: 10.1007/s00330-010-2001-6. Epub 2010 Nov 10.

DOI:10.1007/s00330-010-2001-6

PMID:21063709

Abstract

OBJECTIVE

To analyse the kinetic characteristics of lesions without mass effect in dynamic breast MRI using manual and computer assisted methods.

METHODS

The enhancement pattern of 82 histopathologically verified lesions without mass effect (36 malignant, 46 benign) was evaluated on breast MRI using manual placement of a region of interest. Commercially available computer analysis software automatically assessed volume enhancement characteristics of a lesion voxelwise. Kinetic features evaluated included classification of the signal-intensity time curve as washout, plateau or persistent enhancement.

RESULTS

Unlike manual ROI placement, computer-aided analysis demonstrated a significant difference in enhancement pattern between benign (washout: 32.6%, plateau: 32.6%, persistent: 34.8%) and malignant lesions without mass effect (77.1%, 8.6%, 14.3% respectively, P < 0.01, two-sided Chi-squared test) following initial rapid signal increase. Mean percentage of washout voxel volumes within a lesion was significantly higher in malignant lesions than in benign lesions (11.9% +/-12.7 (SD) vs. 6.9% +/-11.3 (SD), P < 0.01, Mann-Whitney U Test). Conversely, the mean percentage of persistent voxel volumes was significantly lower in malignant lesions than in benign lesions (60.1% +/-21.1 (SD) vs. 79% +/-23 (SD), P < 0.01, Mann-Whitney U Test).

CONCLUSION

Computer-assisted enhancement pattern analysis might have diagnostic benefit in the evaluation of lesions without mass effect.

摘要

目的

使用手动和计算机辅助方法分析无肿块效应的动态乳腺 MRI 病变的动力学特征。

方法

使用手动放置感兴趣区（ROI）评估 82 个经组织病理学证实的无肿块效应病变（36 个恶性，46 个良性）的增强模式。商业上可用的计算机分析软件自动评估病变体素的体积增强特征。评估的动力学特征包括信号强度时间曲线的分类为洗脱、平台或持续增强。

结果

与手动 ROI 放置不同，计算机辅助分析显示，在初始快速信号增加后，良性（洗脱：32.6%，平台：32.6%，持续：34.8%）和无肿块效应恶性病变的增强模式有显著差异（分别为 77.1%、8.6%、14.3%，P < 0.01，双侧卡方检验）。恶性病变中病变内洗脱体素体积的平均百分比明显高于良性病变（11.9% +/-12.7（SD）比 6.9% +/-11.3（SD），P < 0.01，Mann-Whitney U 检验）。相反，恶性病变中持续体素体积的平均百分比明显低于良性病变（60.1% +/-21.1（SD）比 79% +/-23（SD），P < 0.01，Mann-Whitney U 检验）。