Department of Haematology/Oncology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
Ir J Med Sci. 2011 Mar;180(1):85-9. doi: 10.1007/s11845-010-0634-8. Epub 2010 Nov 10.
Overall survival in paediatric cancer has improved significantly over the past 20 years. Treatment strategies have been intensified, and supportive care has made substantial advances. Historically, paediatric oncology patients admitted to an intensive care unit (ICU) have had extremely poor outcomes.
We conducted a retrospective cohort study over a 3-year period in a single centre to evaluate the outcomes for this particularly vulnerable group of patients admitted to a paediatric ICU.
Fifty-five patients were admitted a total of 66 times to the ICU during the study period. The mortality rate of this group was 23% compared with an overall ICU mortality rate of 5%. 11/15 patients who died had an underlying haematological malignancy. Twenty-eight percent of children with organism-identified sepsis died.
While mortality rates for paediatric oncology patients admitted to a ICU have improved, they are still substantial. Those with a haematological malignancy or admitted with sepsis are most at risk.
在过去的 20 年中，儿科癌症的总生存率有了显著提高。治疗策略已经加强，支持性护理也取得了重大进展。从历史上看，入住重症监护病房（ICU）的儿科肿瘤患者的预后极差。
我们在一个中心进行了为期 3 年的回顾性队列研究，以评估入住儿科 ICU 的这一特别脆弱群体患者的结局。
在研究期间，共有 55 名患者总共 66 次被收入 ICU。该组的死亡率为 23%，而整个 ICU 的死亡率为 5%。死亡的 15 名患者中有 11 名患有血液恶性肿瘤。有明确感染源的脓毒症患儿中有 28%死亡。
虽然入住 ICU 的儿科肿瘤患者的死亡率有所改善，但仍然很高。患有血液恶性肿瘤或因败血症入院的患者风险最高。
