Furuno Takashi, Yamasaki Fumiyasu, Yokoyama Takeshi, Sato Kyoko, Sato Takayuki, Doi Yoshinori, Sugiura Tetsuro
Medicine and Geriatrics, Kochi Medical School, Nankoku, Kochi, 783-8505, Japan.
Heart Vessels. 2011 May;26(3):267-73. doi: 10.1007/s00380-010-0054-8. Epub 2010 Nov 10.
Although aspirin has become an established medicine for cardiac and cerebrovascular diseases, the optimal dose remains unknown. We evaluated the optimal dose of aspirin on platelet activity and endothelial function by administering 11 healthy male volunteers (32 ± 6 years of age) doses of aspirin that were increased in a stepwise manner (0, 81, 162, 330 and 660 mg/day) every 3 days. Platelet activity was assessed as surface P-selectin expression (%) measured by flow cytometry and the platelet aggregation ratio. Endothelial function in the brachial artery was assessed by measuring flow-mediated dilation (FMD) before and after reactive hyperemia. Platelet aggregation and P-selectin expression were significantly and dose-dependently suppressed (81-660 mg), and the FMD ratio tended to increase from 0 to 162 mg, but decreased significantly at 660 mg. In conclusion, although aspirin suppressed platelet activity and even surface P-selectin expression, higher doses worsened endothelial-mediated arterial dilation.
尽管阿司匹林已成为治疗心脑血管疾病的常用药物，但其最佳剂量仍不明确。我们通过每3天给11名健康男性志愿者（32±6岁）逐步增加剂量（0、81、162、330和660毫克/天）的阿司匹林，评估了阿司匹林对血小板活性和内皮功能的最佳剂量。血小板活性通过流式细胞术测量的表面P-选择素表达（%）和血小板聚集率进行评估。通过测量反应性充血前后肱动脉的血流介导的血管舒张（FMD）来评估内皮功能。血小板聚集和P-选择素表达在81-660毫克时受到显著的剂量依赖性抑制，FMD比值在0至162毫克时趋于增加，但在660毫克时显著下降。总之，尽管阿司匹林抑制了血小板活性甚至表面P-选择素表达，但更高剂量会使内皮介导的动脉扩张恶化。
