Crisby Milita, Kublickiene Karolina, Henareh Loghman, Agewall Stefan
Department of Neurobiology, Care Sciences and Society, Division of Clinical and Experimental Geriatrics, Karolinska Institute, Karolinska University Hospital - Huddinge, Stockholm, Sweden.
Heart Vessels. 2009 Mar;24(2):90-5. doi: 10.1007/s00380-008-1089-y. Epub 2009 Apr 1.
The association between C-reactive protein (CRP) and future cardiovascular risk has been of particular interest during recent years. Oxidized low-density lipoprotein (ox-LDL) is another marker linking the immune system with the atherogenic process. The aim of this study was to examine whether ox-LDL and CRP were associated with endothelial function in peripheral resistance arteries. Twenty-five men with a previous hospital-diagnosed myocardial infarction were enrolled in the study. The exclusion criterion was a history of diabetes mellitus. IgG and IgM autoantibodies to malonyldialdehyde low-density lipoprotein (MDA-LDL) and high-sensitivity CRP (hs-CRP) were measured. Flow-mediated dilatation was measured in isolated resistance arteries from subcutaneous fat biopsies. Endothelial function test reflecting the maximum vessel dilatation in male subjects was inversely related to MDA-LDL IgG autoantibody levels (r = -0.6 and P = 0.003). Comparison of hs-CRP levels and of maximum vessel dilatation in males revealed also an inverse relation (r= -0.4 and P = 0.04). In conclusion, a clear correlation exists between flow-mediated dilatation in subcutaneous resistance arteries and plasma levels of MDA-LDL IgG autoantibody and CRP in male patients with coronary heart disease.
近年来，C反应蛋白（CRP）与未来心血管疾病风险之间的关联一直备受关注。氧化型低密度脂蛋白（ox-LDL）是另一个将免疫系统与动脉粥样硬化进程联系起来的标志物。本研究的目的是探讨ox-LDL和CRP是否与外周阻力动脉的内皮功能相关。25名曾被医院诊断为心肌梗死的男性纳入本研究。排除标准为糖尿病病史。检测了针对丙二醛低密度脂蛋白（MDA-LDL）的IgG和IgM自身抗体以及高敏CRP（hs-CRP）。通过皮下脂肪活检获取的分离阻力动脉来测量血流介导的血管舒张。反映男性受试者最大血管舒张程度的内皮功能测试与MDA-LDL IgG自身抗体水平呈负相关（r = -0.6，P = 0.003）。男性hs-CRP水平与最大血管舒张程度的比较也显示出负相关（r = -0.4，P = 0.04）。总之，在患有冠心病的男性患者中，皮下阻力动脉的血流介导的血管舒张与血浆MDA-LDL IgG自身抗体水平及CRP之间存在明显的相关性。
