Darling Pam, Huthwaite Mark Arthur
Department of Forensic Psychiatry, Capital and Coast District Health Board, Wellington, New Zealand.
Clin Schizophr Relat Psychoses. 2011 Oct;5(3):159-60. doi: 10.3371/CSRP.5.3.7.
Three case vignettes are presented documenting the rise in serum clozapine that occurred at a time of acute infection in these patients. The literature on this phenomenon is scant. The physiological processes that occur in the acute phase of the inflammatory response are summarized and provide an explanation of how clozapine levels may rise in response to infection. The risk of clozapine toxicity occurring in association with infections is highlighted.
本文呈现了三个病例记录，这些患者在急性感染期间血清氯氮平水平升高。关于这一现象的文献很少。总结了炎症反应急性期发生的生理过程，并解释了氯氮平水平如何因感染而升高。强调了与感染相关的氯氮平毒性风险。
