结核性胸腔积液中的抗纯化蛋白衍生物抗体。
Antipurified-protein-derivative antibody in tuberculous pleural effusions.
作者信息
Murate T, Mizoguchi K, Amano H, Shimokata K, Matsuda T
机构信息
First Department of Medicine, Nagoya University School of Medicine, Japan.
出版信息
Chest. 1990 Mar;97(3):670-3. doi: 10.1378/chest.97.3.670.
Using ELISA, we studied anti-PPD antibody values in 31 tuberculous and 39 carcinomatous pleural effusions. Mean ODI values of anti-PPD IgG, IgA and IgM antibodies in tuberculous pleural effusions were higher than those in carcinomatous pleural effusions (p less than 0.01 in IgG and IgA, p less than 0.05 in IgM antibodies). We also analyzed the detected antigens in PPD and BCG whole cell fraction recognized by IgG antibody in tuberculous pleural effusions. Among heteromolecular components, the antigen band from 25 to 40 Kd region was most frequently stained. This antigen was heat-stable, contained sugar components, and included no disulfide bonds.
我们采用酶联免疫吸附测定法（ELISA），研究了31例结核性和39例癌性胸腔积液中的抗结核菌素纯蛋白衍生物（PPD）抗体值。结核性胸腔积液中抗PPD IgG、IgA和IgM抗体的平均光密度指数（ODI）值高于癌性胸腔积液（IgG和IgA中p<0.01，IgM抗体中p<0.05）。我们还分析了结核性胸腔积液中IgG抗体识别的PPD和卡介苗全细胞组分中的检测抗原。在异分子成分中，25至40 Kd区域的抗原带染色最频繁。该抗原热稳定，含有糖成分，且不含二硫键。
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