Kohonen-Corish M R, King N J, Woodhams C E, Ramshaw I A
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra.
Eur J Immunol. 1990 Jan;20(1):157-61. doi: 10.1002/eji.1830200123.
Recombinant vaccinia viruses (VV)-encoding murine interferon-gamma (IFN-gamma) were constructed and the effect of virus-encoded IFN-gamma on the immune response towards VV in vivo investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN-gamma expression by VV enabled the mice to recover from the infection, whereas mice infected with the control virus died. In normal CBA/H mice also, the growth of VV was greatly reduced and it was cleared faster from mouse organs than the control virus. Natural killer (NK) cell responses in these mice were not enhanced suggesting that this recovery is not NK cell mediated. Other possible mechanisms and implications of this observation are discussed.
构建了编码小鼠γ干扰素（IFN-γ）的重组痘苗病毒（VV），并研究了病毒编码的IFN-γ对体内针对VV免疫反应的影响。在无胸腺裸鼠和亚致死剂量照射的正常胸腺小鼠中，VV表达的IFN-γ使小鼠从感染中恢复，而感染对照病毒的小鼠死亡。在正常CBA/H小鼠中，VV的生长也大大降低，并且与对照病毒相比，它从小鼠器官中清除得更快。这些小鼠中的自然杀伤（NK）细胞反应未增强，表明这种恢复不是由NK细胞介导的。讨论了这一观察结果的其他可能机制及其意义。
