1型人类免疫缺陷病毒感染患者脑脊液中的免疫球蛋白轻链

Free light chains of immunoglobulins in the cerebrospinal fluid of human immunodeficiency virus type 1-infected patients.

作者信息

Gallo P, Piccinno M G, De Rossi A, Pagni S, Amadori A, Chieco-Bianchi L, Tavolato B

机构信息

Institute of Neurology, Interuniversity Center for Research on Cancer, University of Padova, Italy.

出版信息

J Neuroimmunol. 1990 Mar;26(3):229-38. doi: 10.1016/0165-5728(90)90005-8.

DOI:10.1016/0165-5728(90)90005-8

PMID:2106530

Abstract

The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterized by restricted heterogeneity with regard to both isoelectric point and the molecular weight, and were mainly composed by dimers rather than monomers. A striking prevalence of lambda FLC was also observed. Local production of FLC can be taken as a marker of an ongoing immunopathological process within the central nervous system (CNS) in HIV-1-infected patients. A deregulation of Ig production by intrathecally activated B cells may be hypothesized.

摘要

对1型人类免疫缺陷病毒（HIV-1）感染患者的脑脊液（CSF）中免疫球蛋白（Ig）游离轻链（FLC）的存在情况进行了研究。在80%的患者中证实存在FLC的鞘内合成，即使在没有寡克隆Ig的情况下也是如此。FLC模式在等电点和分子量方面具有受限的异质性，并且主要由二聚体而非单体组成。还观察到λFLC的显著优势。FLC的局部产生可被视为HIV-1感染患者中枢神经系统（CNS）内正在进行的免疫病理过程的标志物。可以推测鞘内活化的B细胞对Ig产生的调节失控。