Nakagawa Yoshiko, Shimizu Tetsuo, Terakado Masahiro, Hiranuma Hisato, Matsumoto Ken, Takahashi Noriaki, Hashimoto Shu
Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine.
Nihon Kokyuki Gakkai Zasshi. 2010 Oct;48(10):734-8.
A 65-year-old man consulted our hospital with a complaint of bloody sputum in February 2006, and chest computed tomography (CT) showed a mediastinal tumor. Percutaneous needle biopsy was performed. Pathological examination of the specimen revealed spindle-shaped cells; on immunohistochemical testing the tumor cells were positive for vimentin, keratin, EMA, CD99, actin, alpha-SMA, CD56, NF, and S100, and amplication of the SYT-SSX fusion gene was also seen. Thus, we confirmed a diagnosis of synovial sarcoma. The patient received chemotherapy, radiation therapy and hyperthermia therapy, but the tumor progressed and he died in October 2007. Synovial sarcoma commonly occurs in the vicinity of the large joints. We report an important case of mediastinal synovial sarcoma, which is comparatively rare.
一名65岁男性于2006年2月因咯血痰前来我院就诊，胸部计算机断层扫描（CT）显示纵隔肿瘤。进行了经皮针吸活检。标本的病理检查显示为梭形细胞；免疫组织化学检测显示肿瘤细胞波形蛋白、角蛋白、上皮膜抗原（EMA）、CD99、肌动蛋白、α-平滑肌肌动蛋白（α-SMA）、CD56、神经丝（NF）和S100呈阳性，同时也发现了SYT-SSX融合基因扩增。因此，我们确诊为滑膜肉瘤。该患者接受了化疗、放疗和热疗，但肿瘤仍进展，于2007年10月死亡。滑膜肉瘤常见于大关节附近。我们报告一例重要的纵隔滑膜肉瘤病例，该病相对罕见。
