Peoc'h M, Le Marc'hardour F, Bost F, Pasquier D, Roux J J, Pinel N, Leroux D, Pasquier B
Service d'Anatomie Pathologique, CHU de Grenoble.
Ann Pathol. 1995;15(3):203-6.
A biphasic synovial sarcoma occurring in the anterior and inferior mediastinum in a 19-year-old woman is reported. A biopsy showed a mesenchymal proliferation and the tumor was first misdiagnosed as a hemangiopericytoma. Inefficacy of chemotherapy led to a tumorectomy. Histologic and immunohistochemical studies on multiple samples showed a biphasic tumor. Ultrastructural study confirmed the presence of epithelial elements and cytogenetic analysis disclosed a translocation t(X;18) (p11;q11), leading to a diagnosis of synovial sarcoma. Synovial sarcoma of the mediastinum is very rare and to our knowledge has not been previously studied with the help of cytogenetics. Given the biphasic pattern of the tumor and its mediastinal location, it can be confused with mesothelioma. This stresses the interest of chromosome analysis in the study of tumors histologically difficult to classify.
报告了一名19岁女性前下纵隔发生的双相性滑膜肉瘤。活检显示间叶组织增生，肿瘤最初被误诊为血管外皮细胞瘤。化疗无效后进行了肿瘤切除术。对多个样本的组织学和免疫组化研究显示为双相性肿瘤。超微结构研究证实存在上皮成分，细胞遗传学分析发现t(X;18)(p11;q11)易位，从而诊断为滑膜肉瘤。纵隔滑膜肉瘤非常罕见，据我们所知，此前尚未借助细胞遗传学进行研究。鉴于肿瘤的双相模式及其纵隔位置，它可能会与间皮瘤混淆。这突出了染色体分析在组织学上难以分类的肿瘤研究中的重要性。
