Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead Millennium Institute, The University of Sydney, Australia.
Med Mycol. 2010 Nov;48 Suppl 1:S70-6. doi: 10.3109/13693786.2010.515254.
Members of the Pseudallescheria/Scedosporium species complex are emerging opportunistic fungal pathogens which have the capacity to colonize patients with damaged airways, including those with cystic fibrosis (CF). Assuming human infection is acquired via inhalation of fungal spores from the environment, we performed a qualitative environmental survey encompassing 25 urban, semirural and rural sites in the greater Sydney region to determine the prevalence of Pseudallescheria/Scedosporium species. Soil sampling revealed an abundance of Pseudallescheria/Scedosporium, particularly in locations associated with high human activity. No variation was noted during repeated sampling at different times of the year. Strains of Scedosporium aurantiacum were most frequently isolated (54.6%), followed by Scedosporium prolificans (43%), P. boydii (2.1%) and S. dehoogii (0.3%). The findings coincide with the relatively high prevalence of Scedosporium infections in Australia and their presence as colonizers in CF patients. They emphasize the importance of environmental studies to assess the clinical risk of infection.
假丝酵母/枝顶孢霉种复合体的成员是新兴的机会性真菌病原体，有能力定植于气道受损的患者，包括囊性纤维化（CF）患者。假设人类感染是通过吸入环境中的真菌孢子获得的，我们在大悉尼地区进行了一项涵盖 25 个城市、半城市和农村地区的定性环境调查，以确定假丝酵母/枝顶孢霉种的流行率。土壤采样显示假丝酵母/枝顶孢霉的丰度很高，特别是在与人活动高度相关的地方。在一年中不同时间的重复采样中没有发现变化。最常分离到的是橙色枝顶孢霉（54.6%），其次是枝顶孢霉（43%）、拟青霉（2.1%）和德赫氏枝顶孢霉（0.3%）。这些发现与澳大利亚枝顶孢霉感染的相对高流行率以及它们作为 CF 患者定植菌的存在相一致。它们强调了进行环境研究以评估感染临床风险的重要性。
