L'UNAM Université, Université d'Angers, Groupe d'Etude des Interactions Hôte-Pathogène, EA 3142, Angers, France; Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, Angers, France.
Environ Microbiol. 2015 Apr;17(4):1039-48. doi: 10.1111/1462-2920.12472. Epub 2014 Apr 28.
Species of the Pseudallescheria boydii/Scedosporium apiospermum complex (PSC) are emerging fungal pathogens able to chronically colonize the airways of patients with cystic fibrosis (CF). As P. boydii was found more frequently colonizing the lungs of CF patients in France than in other European countries in a previous report, the present study was conducted in order to clarify distribution of PSC species in France and to characterize their natural habitat. The highest densities of PSC isolates were found in human-impacted areas, i.e. agricultural areas, fluids obtained from wastewater treatment plants, playgrounds and industrial areas. PSC was not detected from soil samples collected in forests. Most PSC culture-positive soil samples exhibited a pH range of 6-8. Scedosporium dehoogii, the most abundant species, was detected in all human-impacted area types except vineyards, whereas Scedosporium aurantiacum was mostly found in agricultural areas. Pseudallescheria boydii and S. apiospermum were predominantly isolated from seashores and playgrounds respectively. Pseudallescheria minutispora was found only once from a playground. This study highlights potential sources of contamination of the patients, especially in the CF context.
假丝酵母/枝孢霉复合种（PSC）的物种是新兴的真菌病原体，能够在囊性纤维化（CF）患者的气道中慢性定植。由于之前的一份报告发现，在法国，PSC 比其他欧洲国家更频繁地定植于 CF 患者的肺部，因此本研究旨在阐明法国 PSC 种的分布情况，并对其天然栖息地进行特征描述。PSC 分离株的最高密度出现在受人类影响的地区，即农业区、污水处理厂的液体、游乐场和工业区。在森林中采集的土壤样本未检测到 PSC。大多数 PSC 培养阳性的土壤样本的 pH 值范围为 6-8。除了葡萄园之外，所有受人类影响的区域类型都检测到了最丰富的物种枝孢霉，而 Scedosporium aurantiacum 主要存在于农业区。假丝酵母和 S. apiospermum 主要分别从海滨和游乐场中分离得到。假丝酵母微小球菌仅从一个游乐场中分离得到一次。本研究强调了患者的潜在污染来源，特别是在 CF 环境中。
