National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Clin Infect Dis. 2010 Dec 15;51(12):1442-4. doi: 10.1086/657429. Epub 2010 Nov 10.
It is impossible to know with certainty the first time that an influenza virus infected humans or when the first influenza pandemic occurred. However, many historians agree that the year 1510 a.d.-500 years ago-marks the first recognition of pandemic influenza. On this significant anniversary it is timely to ask: what were the circumstances surrounding the emergence of the 1510 pandemic, and what have we learned about this important disease over the subsequent five centuries? We conclude that in recent decades significant progress has been made in diagnosis, prevention, control, and treatment of influenza. It seems likely that, in the foreseeable future, we may be able to greatly reduce the burden of influenza pandemics with improved vaccines and other scientific and public health approaches.
要确切地知道首例流感病毒感染人类的时间或者首次流感大流行发生的时间是不可能的。然而，许多历史学家都认为公元 1510 年——500 年前——标志着大流行性流感的首次确认。在这个重要的周年纪念日，适时地提出以下问题：1510 年大流行出现的情况如何？在随后的 5 个世纪里，我们对这种重要疾病有了哪些了解？我们的结论是，近几十年来，在流感的诊断、预防、控制和治疗方面已经取得了重大进展。在可预见的未来，我们似乎有可能通过改进疫苗和其他科学及公共卫生方法，大大减轻流感大流行的负担。
