Genetics, epigenetics, and leukemia.
作者信息
Shannon Kevin, Armstrong Scott A
出版信息
N Engl J Med. 2010 Dec 16;363(25):2460-1. doi: 10.1056/NEJMe1012071. Epub 2010 Nov 10.
Abstract
摘要
相似文献
1
Genetics, epigenetics, and leukemia.遗传学、表观遗传学与白血病。
N Engl J Med. 2010 Dec 16;363(25):2460-1. doi: 10.1056/NEJMe1012071. Epub 2010 Nov 10.
2
DNMT3A mutations in acute myeloid leukemia.DNMT3A 基因突变与急性髓系白血病。
Nat Genet. 2011 Mar 29;43(4):289-90. doi: 10.1038/ng0411-289.
3
DNMT3A mutations at R882 hotspot are only found in major clones of acute myeloid leukemia.仅在急性髓系白血病的主要克隆中发现R882热点处的DNMT3A突变。
Leuk Lymphoma. 2014 Mar;55(3):711-4. doi: 10.3109/10428194.2013.811580. Epub 2013 Jul 25.
4
DNMT3A mutations in acute myeloid leukemia: impact on low-risk patients with CEBPA mutations.急性髓系白血病中的DNMT3A突变：对伴有CEBPA突变的低风险患者的影响。
J Clin Oncol. 2011 Dec 1;29(34):4592-3; author reply 4593-4. doi: 10.1200/JCO.2011.38.2127. Epub 2011 Oct 31.
5
DNMT3A mutations are rare in childhood acute myeloid leukemia.DNA甲基转移酶3A（DNMT3A）突变在儿童急性髓系白血病中较为罕见。
Haematologica. 2011 Aug;96(8):1238-40. doi: 10.3324/haematol.2011.046839. Epub 2011 Jun 17.
6
Mutant DNMT3A in acute myeloid leukemia: guilty of inducing genetic instability?急性髓系白血病中的突变型DNMT3A：是否导致基因不稳定之罪？
Leukemia. 2013 Aug;27(8):1777-8. doi: 10.1038/leu.2013.48. Epub 2013 Feb 18.
7
Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.主导负性：DNMT3A 突变如何促进 AML 的发病机制。
Cell Stem Cell. 2017 Jan 5;20(1):7-8. doi: 10.1016/j.stem.2016.12.008.
8
Rapid detection of DNMT3A R882 codon mutations allows early identification of poor risk patients with acute myeloid leukemia.快速检测DNMT3A R882密码子突变可实现对急性髓系白血病低危患者的早期识别。
Leuk Lymphoma. 2013 Jun;54(6):1336-9. doi: 10.3109/10428194.2012.736986. Epub 2012 Nov 1.
9
Acute myeloid leukemia cells exhibit selective down-regulation of DNMT3A isoform 2.急性髓系白血病细胞表现出DNMT3A亚型2的选择性下调。
Leuk Lymphoma. 2015;56(12):3445-8. doi: 10.3109/10428194.2015.1032965. Epub 2015 Jun 19.
10
DNMT3A R882H mutation in acute myeloid leukemia cell line SET-2.
Leuk Res. 2020 Jan;88:106270. doi: 10.1016/j.leukres.2019.106270. Epub 2019 Nov 9.
引用本文的文献
1
A real-world study of adverse drug reactions of two isocitrate dehydrogenase inhibitor based on the US FDA adverse event reporting system and VigiAccess databases.一项基于美国食品药品监督管理局不良事件报告系统和VigiAccess数据库的两种异柠檬酸脱氢酶抑制剂药物不良反应的真实世界研究。
Front Pharmacol. 2024 Nov 7;15:1489045. doi: 10.3389/fphar.2024.1489045. eCollection 2024.
2
Cytarabine delivered by CD44 and bone targeting redox-sensitive liposomes for treatment of acute myelogenous leukemia.通过CD44和骨靶向氧化还原敏感脂质体递送阿糖胞苷用于治疗急性髓性白血病。
Regen Biomater. 2022 Aug 24;9:rbac058. doi: 10.1093/rb/rbac058. eCollection 2022.
3
Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives.髓系白血病发生机制：当前观点与治疗目标。
Blood Rev. 2023 Jan;57:100996. doi: 10.1016/j.blre.2022.100996. Epub 2022 Aug 2.
4
Editorial: Mechanisms of Epigenetics and Genetics in Leukemogenesis.社论：白血病发生过程中的表观遗传学和遗传学机制
Front Oncol. 2022 Apr 7;12:896094. doi: 10.3389/fonc.2022.896094. eCollection 2022.
5
DNA Methylation and Uveal Melanoma.DNA 甲基化与葡萄膜黑色素瘤。
Chin Med J (Engl). 2018 Apr 5;131(7):845-851. doi: 10.4103/0366-6999.228229.
6
CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells.CRYAA启动子中的CpG位点甲基化影响人晶状体上皮细胞中转录因子Sp1的结合。
BMC Ophthalmol. 2016 Aug 9;16:141. doi: 10.1186/s12886-016-0309-y.
7
Epigenetic regulation in cardiac fibrosis.心脏纤维化中的表观遗传调控。
World J Cardiol. 2015 Nov 26;7(11):784-91. doi: 10.4330/wjc.v7.i11.784.
8
BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression.BMI1通过在恶性髓系进展过程中直接与Zmym3结合，重新编程组蛋白乙酰化并增强c-fos信号通路。
J Cell Mol Med. 2014 Jun;18(6):1004-17. doi: 10.1111/jcmm.12246. Epub 2014 Feb 27.
9
The myth of genetic enhancement.基因增强的谬论。
Theor Med Bioeth. 2012 Jun;33(3):163-78. doi: 10.1007/s11017-012-9220-6.
本文引用的文献
1
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.造血祖细胞向谱系定向分化的全甲基化组图谱
Nature. 2010 Sep 16;467(7313):338-42. doi: 10.1038/nature09367. Epub 2010 Aug 15.
2
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.骨髓增生异常综合征中组蛋白甲基转移酶基因 EZH2 的体细胞突变。
Nat Genet. 2010 Aug;42(8):665-7. doi: 10.1038/ng.620. Epub 2010 Jul 4.
3
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.在髓系疾病中，组蛋白甲基转移酶基因 EZH2 的失活突变。
Nat Genet. 2010 Aug;42(8):722-6. doi: 10.1038/ng.621. Epub 2010 Jul 4.
4
Array-based genomic resequencing of human leukemia.基于阵列的人类白血病基因组重测序。
Oncogene. 2010 Jun 24;29(25):3723-31. doi: 10.1038/onc.2010.117. Epub 2010 Apr 19.
5
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.生发中心来源的滤泡性和弥漫性大 B 细胞淋巴瘤中 EZH2（Tyr641）改变的体细胞突变。
Nat Genet. 2010 Feb;42(2):181-5. doi: 10.1038/ng.518. Epub 2010 Jan 17.
6
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.DNA甲基化保护造血干细胞多能性免受髓系红系限制。
Nat Genet. 2009 Nov;41(11):1207-15. doi: 10.1038/ng.463. Epub 2009 Oct 4.
7
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.DNA甲基转移酶1对造血干细胞和祖细胞至关重要且具有独特的调控作用。
Cell Stem Cell. 2009 Oct 2;5(4):442-9. doi: 10.1016/j.stem.2009.08.016.
8
Recurring mutations found by sequencing an acute myeloid leukemia genome.通过对急性髓系白血病基因组进行测序发现的复发性突变。
N Engl J Med. 2009 Sep 10;361(11):1058-66. doi: 10.1056/NEJMoa0903840. Epub 2009 Aug 5.
9
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.人类癌症中组蛋白H3K27去甲基化酶基因UTX的体细胞突变。
Nat Genet. 2009 May;41(5):521-3. doi: 10.1038/ng.349. Epub 2009 Mar 29.
Zotero 插件