Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Cell Stem Cell. 2017 Jan 5;20(1):7-8. doi: 10.1016/j.stem.2016.12.008.
Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant protein contributes to AML using a combination of mouse genetics and primary patient samples.
DNMT3A 中的体细胞突变是急性髓细胞白血病 (AML) 患者中最常见的遗传异常之一。Guryanova 等人的一项新研究结合使用小鼠遗传学和原发性患者样本，深入了解最常见的 DNMT3A 变异蛋白如何导致 AML。
