Tshwane University of Technology, Department of Pharmaceutical Sciences, Pretoria, South Africa.
Expert Opin Drug Metab Toxicol. 2010 Dec;6(12):1515-38. doi: 10.1517/17425255.2010.529129. Epub 2010 Nov 11.
the global increase in the popularity of alternative medicines has raised renewed concerns regarding herb-drug interactions. These interactions are especially important for drugs with narrow therapeutic indices and may either be pharmacodynamic or pharmacokinetic in nature.
pharmacokinetic interactions which may exist between herbs and drugs, and the mechanisms of these interactions with appropriate examples based on primary and secondary data in publications are discussed. The mechanisms covered include those that affect oral drug absorption (e.g., modulation of efflux and uptake transporters, complex formation, gastrointestinal motility and pH) and drug biotransformation (e.g., inhibition or induction of enzymes).
knowledge on the mechanisms of herb-drug pharmacokinetic interactions supported by an extended list of these types of interactions for quick reference. A critical evaluation of certain herb-drug pharmacokinetic interactions reported in the scientific literature.
as the incidence and severity of herb-drug pharmacokinetic interactions increase due to a worldwide rise in the use of herbal preparations, more clinical data regarding herb-drug pharmacokinetic interactions are needed to make informed decisions regarding patient safety.
替代药物在全球范围内的普及，重新引发了人们对草药-药物相互作用的关注。这些相互作用对于治疗指数较窄的药物尤为重要，可能具有药效学或药代动力学性质。
讨论了草药和药物之间可能存在的药代动力学相互作用，以及基于出版物中的原始和次要数据的这些相互作用机制的适当示例。涵盖的机制包括影响口服药物吸收的机制（例如，外排和摄取转运体的调节、络合形成、胃肠道动力和 pH）和药物生物转化（例如，酶的抑制或诱导）。
支持草药-药物药代动力学相互作用机制的知识，以及这些类型相互作用的扩展列表，可作为快速参考。对科学文献中报告的某些草药-药物药代动力学相互作用的批判性评估。
由于全球范围内草药制剂使用的增加，草药-药物药代动力学相互作用的发生率和严重程度增加，因此需要更多关于草药-药物药代动力学相互作用的临床数据，以便就患者安全做出明智的决策。
