Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA.
J Neurosci. 2010 Nov 10;30(45):14980-6. doi: 10.1523/JNEUROSCI.4283-10.2010.
Endocannabinoid signaling is distributed throughout the brain, regulating synaptic release of both excitatory and inhibitory neurotransmitters. The presence of endocannabinoid signaling within stress-sensitive nuclei of the hypothalamus, as well as upstream limbic structures such as the amygdala, suggests it may play an important role in regulating the neuroendocrine and behavioral effects of stress. The evidence reviewed here demonstrates that endocannabinoid signaling is involved in both activating and terminating the hypothalamic-pituitary-adrenal axis response to both acute and repeated stress. In addition to neuroendocrine function, however, endocannabinoid signaling is also recruited by stress and glucocorticoid hormones to modulate cognitive and emotional processes such as memory consolidation and extinction. Collectively, these data demonstrate the importance of endocannabinoid signaling at multiple levels as both a regulator and an effector of the stress response.
内源性大麻素信号分布于整个大脑，调节兴奋性和抑制性神经递质的突触释放。内源性大麻素信号存在于下丘脑的应激敏感核团以及边缘系统的上游结构如杏仁核内，提示其可能在调节应激的神经内分泌和行为效应中发挥重要作用。本文综述的证据表明，内源性大麻素信号参与了激活和终止下丘脑-垂体-肾上腺轴对急性和重复应激的反应。然而，除了神经内分泌功能，内源性大麻素信号还被应激和糖皮质激素招募，以调节认知和情绪过程，如记忆巩固和遗忘。总的来说，这些数据表明内源性大麻素信号在多个水平上的重要性，既是应激反应的调节剂，也是其效应器。
