Ikehata Tsutomu, Wada Yoshihiro, Ishikawa Yoshiharu, Kadota Koichi
Tokachi Livestock Hygiene Service Center, 59–6 Kisen, Kawanishi, Obihiro 089–1182, Japan.
J Vet Med Sci. 2011 Apr;73(4):467-70. doi: 10.1292/jvms.10-0378. Epub 2010 Nov 5.
A diagnosis of acute myeloid leukemia was made in a 10-month-old Holstein female calf. The leukemia was macroscopically characterized by great enlargement of the spleen and moderate enlargement of some lymph nodes. Histochemical and immunohistochemical examination disclosed the presence of neoplastic cells either containing metachromatic and tryptase-positive granules or expressing factor VIII-related antigen. The granules, which were positive for naphthol AS-D chloroacetate esterase and did not have particulate contents, were distinct from those of basophilic leukemia cells. This leukemia was thought to be derived from a common myeloid progenitor capable of giving rise to megakaryocyte-erythrocyte progenitors and granulocyte-monocyte progenitors with the ability to differentiate into mast cells.
一头10个月大的荷斯坦雌性犊牛被诊断为急性髓系白血病。从宏观上看，白血病的特征是脾脏显著肿大，一些淋巴结中度肿大。组织化学和免疫组织化学检查发现，肿瘤细胞要么含有异染性且对类胰蛋白酶呈阳性反应的颗粒，要么表达因子VIII相关抗原。这些颗粒对萘酚AS-D氯乙酸酯酶呈阳性反应且没有颗粒状内含物，与嗜碱性白血病细胞的颗粒不同。这种白血病被认为源自一种常见的髓系祖细胞，该祖细胞能够产生巨核细胞 - 红细胞祖细胞以及具有分化为肥大细胞能力的粒细胞 - 单核细胞祖细胞。
