Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, People's Republic of China.
Arch Gynecol Obstet. 2011 Mar;283 Suppl 1:107-10. doi: 10.1007/s00404-010-1717-5. Epub 2010 Nov 11.
To identify patients with highly elevated serum CA-125 levels and analyze their clinical characteristics.
Patients with non-malignant gynecologic disease (NMGDs, n = 41), in whom serum CA-125 levels were over 1,000 IU/ml were retrospectively enrolled in the study. Seventy-one patients with epithelial ovarian cancer (EOC), in whom, serum CA-125 levels were over 1,000 IU/ml were included as the comparison group. Clinical parameters were compared between the two groups.
In NMGDs group, 43.90% of the patients had endometriosis. The median of serum CA-125 level in NMGDs was much lower than that of EOC subjects (P < 0.001). Compared to EOC group, the patients in NMGDs group were much younger (P < 0.001) and had fewer histories of pelvic masses (P < 0.001) but had more clinical complaints such as acute abdominal symptoms (P < 0.001) and/or abnormal vaginal bleeding (P = 0.022). Clinical progresses of these two groups were correlated with changes of serum CA-125 levels by follow-up for up to 386 days.
High levels of serum CA-125 were found not only in the EOC, but also in some NMGDs, especially in the reproductive patients with complaints of acute abdomen symptoms or abnormal vaginal bleeding.
识别血清 CA-125 水平显著升高的患者，并分析其临床特征。
回顾性纳入患有非恶性妇科疾病（NMGD，n=41）且血清 CA-125 水平超过 1000IU/ml 的患者。纳入 71 例血清 CA-125 水平超过 1000IU/ml 的上皮性卵巢癌（EOC）患者作为比较组。比较两组的临床参数。
在 NMGD 组中，43.90%的患者患有子宫内膜异位症。NMGD 组的血清 CA-125 水平中位数明显低于 EOC 组（P<0.001）。与 EOC 组相比，NMGD 组的患者更年轻（P<0.001），盆腔肿块史更少（P<0.001），但有更多的临床症状，如急性腹痛症状（P<0.001）和/或异常阴道出血（P=0.022）。通过长达 386 天的随访，这两组的临床进展与血清 CA-125 水平的变化相关。
高水平的血清 CA-125 不仅存在于 EOC 中，也存在于某些 NMGD 中，特别是在有急性腹痛症状或异常阴道出血等症状的生殖系统患者中。
