Brooks C D, Karl K J, Francom S F
Upjohn Research Clinics, Bronson Clinical Investigation Unit, Bronson Methodist Hospital, Kalamazoo, MI 49007.
Clin Exp Allergy. 1990 Jan;20(1):21-6. doi: 10.1111/j.1365-2222.1990.tb02770.x.
Forty-two ragweed hay fever patients participated in a study which examined the profile of symptom relief provided by terfenadine, and the relative adequacy of symptom control with the drug given from the beginning of the season compared with treatment started after symptoms were well established. Compared with placebo, terfenadine effectively relieved sneeze, itch and eye symptoms. It had no effect on running, blowing and drainage. Subjectively perceived congestion benefited marginally. When the drug was begun after symptoms were well established, sneezing responded quickly and maximally. Eye discomfort lessened but not to the level experienced by those dosed from the beginning of the season. The pattern in other symptom categories was less clear. Overall, terfenadine improved all rhinitis symptoms except those related to hypersecretion. Some symptoms appeared to respond better when drug dosing commenced at the beginning of the season.
42名豚草花粉热患者参与了一项研究，该研究考察了特非那定提供的症状缓解情况，以及从季节开始就服用该药与在症状充分出现后开始治疗相比，症状控制的相对充分程度。与安慰剂相比，特非那定能有效缓解打喷嚏、瘙痒和眼部症状。它对流鼻涕、擤鼻和流涕没有作用。主观感觉到的鼻塞仅有轻微改善。在症状充分出现后开始使用该药时，打喷嚏反应迅速且最大程度缓解。眼部不适减轻，但未达到从季节开始就用药者的体验水平。其他症状类别的模式不太清晰。总体而言，特非那定改善了所有鼻炎症状，但与分泌亢进相关的症状除外。当在季节开始时开始给药时，一些症状似乎反应更好。
