原发性皮肤淀粉样变性与特应性皮炎的相关性：台湾一项全国性基于人群的研究。

Association of primary cutaneous amyloidosis with atopic dermatitis: a nationwide population-based study in Taiwan.

机构信息

Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.

出版信息

Br J Dermatol. 2011 Jan;164(1):148-53. doi: 10.1111/j.1365-2133.2010.10024.x. Epub 2010 Nov 11.

DOI:10.1111/j.1365-2133.2010.10024.x

PMID:21070198

Abstract

BACKGROUND

Primary cutaneous amyloidosis (PCA) is a pruritic skin disorder most commonly seen in Southeast Asia and South America. Association of PCA with atopic dermatitis (AD) has been reported in the literature. However, no large-scale epidemiological study of PCA and its associations with other diseases has been conducted so far.

OBJECTIVES

We aimed to provide overall demographic data and comorbidities of patients with PCA based on a nationwide database in Taiwan.

METHODS

Cases of PCA were collected from records of National Health Insurance claims from 2000 to 2007. We analysed patients' gender, age when the diagnosis was first made, and the overall 8-year prevalence. We also investigated comorbidities.

RESULTS

The overall 8-year prevalence of PCA was 7·87 per 10,000 persons. Although there was no significant gender difference in the prevalence of PCA, men and women showed a different peak age (men, 71-80 years; women, 41-50 years) and a different age distribution at diagnosis. The mean age at diagnosis of PCA was significantly younger for women than for men. Men sought medical assistance for PCA more frequently than women. There was a higher disease activity from May to September than during other months. PCA was strongly associated with AD (odds ratio 7·18). Patients with PCA had a higher comorbidity of hyperlipidaemia and diabetes mellitus.

CONCLUSIONS

This is the first nationwide population-based epidemiological study of PCA. We demonstrate that PCA can be associated with other disorders, especially AD.

摘要

背景

原发性皮肤淀粉样变性（PCA）是一种瘙痒性皮肤病，最常见于东南亚和南美洲。文献中已有 PCA 与特应性皮炎（AD）相关的报道。然而，迄今为止，尚未对 PCA 及其与其他疾病的相关性进行大规模的流行病学研究。

目的

我们旨在根据台湾的全国性数据库，提供 PCA 患者的总体人口统计学数据和合并症。

方法

从 2000 年至 2007 年的国民健康保险理赔记录中收集 PCA 病例。我们分析了患者的性别、首次诊断时的年龄以及 8 年的总体患病率。我们还调查了合并症。

结果

PCA 的 8 年总体患病率为 7.87/10000 人。虽然 PCA 的患病率在性别之间没有显著差异，但男性和女性的发病高峰年龄不同（男性为 71-80 岁；女性为 41-50 岁），发病时的年龄分布也不同。PCA 的平均发病年龄女性明显小于男性。男性比女性更频繁地因 PCA 寻求医疗帮助。5 月至 9 月的疾病活动度高于其他月份。PCA 与 AD 密切相关（优势比 7.18）。患有 PCA 的患者合并高脂血症和糖尿病的几率更高。