Chang Y T, Liu H N, Wong C K, Chow K C, Chen K Y
Department of Dermatology, National Yang-Ming University, Taipei, Taiwan.
Br J Dermatol. 1997 Jun;136(6):823-6.
To determine the association of Epstein-Barr virus (EBV) with primary cutaneous amyloidosis (PCA), a retrospective study was conducted on skin tissue from 27 Chinese patients with lichen amyloidosus and macular amyloidosis. In situ hybridization with oligonucleotide probes was used to detect the expression of EBV-encoded RNAs (EBERs). Eleven of 27 cases (40.7%) were found to contain the EBV genome. No EBV genome was detected in the skin of the control groups, including three cases of secondary cutaneous amyloidosis, two cases of primary systemic amyloidosis, and four cases of lichen simplex chronicus. Our study showed no correlation between the presence of EBV in PCA patients and the patients' age, sex, clinical type or severity of the skin lesions. Although our results suggest that EBV may be associated with some cases of PCA, the true aetiological role of EBV in PCA remains unknown.
为确定爱泼斯坦-巴尔病毒（EBV）与原发性皮肤淀粉样变（PCA）之间的关联，对27例苔藓样淀粉样变和斑状淀粉样变中国患者的皮肤组织进行了一项回顾性研究。使用寡核苷酸探针原位杂交检测EBV编码RNA（EBERs）的表达。27例病例中有11例（40.7%）被发现含有EBV基因组。在对照组的皮肤中未检测到EBV基因组，对照组包括3例继发性皮肤淀粉样变、2例原发性系统性淀粉样变和4例慢性单纯性苔藓。我们的研究表明，PCA患者中EBV的存在与患者的年龄、性别、临床类型或皮肤病变严重程度之间无相关性。尽管我们的结果提示EBV可能与部分PCA病例有关，但EBV在PCA中的真正病因学作用仍不清楚。
