Winand R, Wadeleux P, Etienne-Decerf J
Ann Endocrinol (Paris). 1978;39(2):139-40.
Thyrotropin induces the formation of a follicular structure of thyroid cells in tissue culture. It produces an increase in cyclic AMP content of thyrotropin treated cells. Thyrotropin induces on increase in iodine incorporation with the appearance of iodinated proteins which are mostly 19 S. thyroglobulin. In goiters, the level of cyclic AMP and the stimulation with thyrotropin differs from normal conditions indicating differences in cell metabolism and differences in the properties of the receptor. Thyrotropin also gives an increase in uridine incorporation in RNA and on increase not only in poly A but also in poly A-RNA associated with heavy polysomes. The level of poly A is higher in toxic adenoma and lower in microfollicular adenoma as compared to colloido nodular goiter which is in good agreement with our knowledge of thyroid cell metabolism.
促甲状腺激素在组织培养中诱导甲状腺细胞形成滤泡结构。它使促甲状腺激素处理过的细胞中的环磷酸腺苷含量增加。促甲状腺激素诱导碘掺入增加，并出现碘化蛋白质，这些蛋白质大多是19S甲状腺球蛋白。在甲状腺肿中，环磷酸腺苷水平以及促甲状腺激素刺激与正常情况不同，表明细胞代谢存在差异以及受体特性存在差异。促甲状腺激素还使尿苷掺入RNA增加，不仅使多聚腺苷酸增加，而且使与重多核糖体相关的多聚腺苷酸-RNA增加。与胶样结节性甲状腺肿相比，毒性腺瘤中的多聚腺苷酸水平较高，微滤泡性腺瘤中的多聚腺苷酸水平较低，这与我们对甲状腺细胞代谢的认识相符。
