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Contemp Clin Trials. 2011 Mar;32(2):240-3. doi: 10.1016/j.cct.2010.11.004. Epub 2010 Nov 9.
The use of blinding strengthens the credibility of randomized controlled trials (RCTs) by minimizing bias. However, there is confusion surrounding the definition of blinding as well as the terms single, double, and triple blind. It has been suggested that these terms should be discontinued due to their broad misinterpretation. We recommend that, instead of abandoning the use of these terms, explicit definitions of blinding should be adopted. We address herein the concept of blinding, propose standard definitions for the consistent use of these terms, and detail when different types of blinding should be utilized. Standardizing the definition of blinding and utilizing proper blinding methods will improve the quality and clarity of reporting in RCTs.
盲法的使用通过最小化偏倚来增强随机对照试验 (RCT) 的可信度。然而，盲法的定义以及单盲、双盲和三盲这些术语的含义存在混淆。有人建议由于这些术语被广泛误解，应该停止使用这些术语。我们建议，不应该放弃这些术语的使用，而应采用盲法的明确定义。本文旨在阐述盲法的概念，提出这些术语的标准定义，详细说明何时应使用不同类型的盲法。标准化盲法的定义并使用适当的盲法方法将提高 RCT 报告的质量和清晰度。
