为组蛋白 H4 单甲基化设置时钟。
SETting the clock for histone H4 monomethylation.
机构信息
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
出版信息
Mol Cell. 2010 Nov 12;40(3):345-6. doi: 10.1016/j.molcel.2010.10.033.
Abstract
In this and a previous issue of Molecular Cell, Oda et al. (2010), Abbas et al. (2010), and Centore et al. (2010) determined that the H4K20 histone methyltransferase PR-Set7/Set8 is posttranslationally regulated by the PCNA-dependent CRL4(Cdt2) ubiquitin ligase.
摘要
在这篇和之前的Molecular Cell 杂志中，Oda 等人（2010）、Abbas 等人（2010）和 Centore 等人（2010）确定 H4K20 组蛋白甲基转移酶 PR-Set7/Set8 受到 PCNA 依赖性 CRL4(Cdt2)泛素连接酶的翻译后调控。
相似文献
1
SETting the clock for histone H4 monomethylation.为组蛋白 H4 单甲基化设置时钟。
Mol Cell. 2010 Nov 12;40(3):345-6. doi: 10.1016/j.molcel.2010.10.033.
2
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.CRL4(Cdt2) 通过靶向 PR-Set7/Set8 进行降解来调节细胞增殖和组蛋白基因表达。
Mol Cell. 2010 Oct 8;40(1):9-21. doi: 10.1016/j.molcel.2010.09.014.
3
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.组蛋白 H4 一甲基转移酶 PR-Set7 的调控：在 DNA 损伤过程中，CRL4(Cdt2) 介导的 PCNA 依赖性降解。
Mol Cell. 2010 Nov 12;40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28.
4
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.SET8 在 S 期和 UV 照射后通过 PCNA 偶联的 CRL4（CDT2）泛素化降解。
J Cell Biol. 2011 Jan 10;192(1):43-54. doi: 10.1083/jcb.201009076.
5
A new regulator of the cell cycle: the PR-Set7 histone methyltransferase.一种新的细胞周期调控因子：PR-Set7 组蛋白甲基转移酶。
Cell Cycle. 2011 Jan 1;10(1):68-72. doi: 10.4161/cc.10.1.14363.
6
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.CRL4(Cdt2) 介导的组蛋白甲基转移酶 Set8 的降解可防止 S 期过早发生染色质浓缩。
Mol Cell. 2010 Oct 8;40(1):22-33. doi: 10.1016/j.molcel.2010.09.015.
7
CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.细胞周期蛋白依赖性激酶1（CDK1）对E3泛素连接酶CRL4CDT2的抑制作用确保了从S期到有丝分裂的稳健过渡。
J Biol Chem. 2015 Jan 2;290(1):556-67. doi: 10.1074/jbc.M114.614701. Epub 2014 Nov 19.
8
Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.CRL4-CDT2-SET8/p21泛素化和降解轴的失活是pevonedistat治疗黑色素瘤疗效的基础。
EBioMedicine. 2016 Aug;10:85-100. doi: 10.1016/j.ebiom.2016.06.023. Epub 2016 Jun 16.
9
CRL4 Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA.CRL4 泛素连接酶，受 Cdt2 与 PCNA 和 DNA 结合控制的基因组守护者。
Genes (Basel). 2022 Jan 29;13(2):266. doi: 10.3390/genes13020266.
10
The role of PR-Set7 in replication licensing depends on Suv4-20h.PR-Set7 在复制许可中的作用依赖于 Suv4-20h。
Genes Dev. 2012 Dec 1;26(23):2580-9. doi: 10.1101/gad.195636.112. Epub 2012 Nov 14.
引用本文的文献
1
Prdm6 controls heart development by regulating neural crest cell differentiation and migration.Prdm6 通过调控神经嵴细胞的分化和迁移来控制心脏发育。
JCI Insight. 2022 Feb 2;7(4):e156046. doi: 10.1172/jci.insight.156046.
2
The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin.微管相关组蛋白甲基转移酶 SET8 在转录因子 LSF 的协助下，对α-微管蛋白进行甲基化修饰。
J Biol Chem. 2020 Apr 3;295(14):4748-4759. doi: 10.1074/jbc.RA119.010951. Epub 2020 Feb 28.
3
Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate.Set8组蛋白甲基转移酶与其核小体底物的多价相互作用。
J Mol Biol. 2016 Apr 24;428(8):1531-43. doi: 10.1016/j.jmb.2016.02.025. Epub 2016 Mar 4.
4
SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation.干细胞因子（β-转导素重复序列包含蛋白）通过靶向PR-Set7/Set8进行降解来促进细胞生长。
Nat Commun. 2015 Dec 15;6:10185. doi: 10.1038/ncomms10185.
5
Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time.组蛋白H4赖氨酸20（H4K20）甲基化：一次一个甲基基团拓展蛋白质组的信号传导潜能
Mol Cell Proteomics. 2016 Mar;15(3):755-64. doi: 10.1074/mcp.R115.054742. Epub 2015 Nov 23.
6
The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications.CRL4 E3泛素连接酶在癌症中的作用机制及其潜在的治疗意义。
Oncotarget. 2015 Dec 15;6(40):42590-602. doi: 10.18632/oncotarget.6052.
7
The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies.CUL4A泛素连接酶是皮肤癌和其他恶性肿瘤潜在的治疗靶点。
Chin J Cancer. 2013 Sep;32(9):478-82. doi: 10.5732/cjc.012.10279. Epub 2013 Jul 12.
8
Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.染色质重塑酶蔗糖非发酵物 2 同源物（SNF2H）通过与 Cdc10 蛋白依赖性转录物 1（Cdt1）的相互作用被招募到 DNA 复制起点，并促进复制前复合物的形成。
J Biol Chem. 2011 Nov 11;286(45):39200-10. doi: 10.1074/jbc.M111.256123. Epub 2011 Sep 20.
本文引用的文献
1
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.组蛋白 H4 一甲基转移酶 PR-Set7 的调控：在 DNA 损伤过程中，CRL4(Cdt2) 介导的 PCNA 依赖性降解。
Mol Cell. 2010 Nov 12;40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28.
2
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells.组蛋白 H4 赖氨酸 20 甲基转移酶 PR-Set7 调控哺乳动物细胞中的复制起点。
Nat Cell Biol. 2010 Nov;12(11):1086-93. doi: 10.1038/ncb2113. Epub 2010 Oct 17.
3
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.CRL4(Cdt2) 介导的组蛋白甲基转移酶 Set8 的降解可防止 S 期过早发生染色质浓缩。
Mol Cell. 2010 Oct 8;40(1):22-33. doi: 10.1016/j.molcel.2010.09.015.
4
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.CRL4(Cdt2) 通过靶向 PR-Set7/Set8 进行降解来调节细胞增殖和组蛋白基因表达。
Mol Cell. 2010 Oct 8;40(1):9-21. doi: 10.1016/j.molcel.2010.09.014.
5
Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2.将一个特殊的增殖细胞核抗原相互作用基序（PIP Box）对接至与染色质结合的增殖细胞核抗原（PCNA）上，会为泛素连接酶Cullin4-DDB1-Cdt2（CRL4Cdt2）创造一个降解结构域。
Mol Cell. 2009 Jul 10;35(1):93-104. doi: 10.1016/j.molcel.2009.05.012.
6
The multiple facets of histone H4-lysine 20 methylation.组蛋白H4赖氨酸20甲基化的多个方面。
Biochem Cell Biol. 2009 Feb;87(1):151-61. doi: 10.1139/O08-131.
7
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.组蛋白H4赖氨酸20的单甲基化参与染色体结构和稳定性的维持，对小鼠发育至关重要。
Mol Cell Biol. 2009 Apr;29(8):2278-95. doi: 10.1128/MCB.01768-08. Epub 2009 Feb 17.
8
PCNA, the maestro of the replication fork.增殖细胞核抗原（PCNA），复制叉的指挥者。
Cell. 2007 May 18;129(4):665-79. doi: 10.1016/j.cell.2007.05.003.
9
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells.众志成城：真核细胞中通过多种机制防止再复制
Genes Dev. 2007 Mar 1;21(5):497-518. doi: 10.1101/gad.1508907.
10
Dynamics of pre-replication complex proteins during the cell division cycle.细胞分裂周期中复制前复合体蛋白的动态变化。
Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):7-16. doi: 10.1098/rstb.2003.1360.
Zotero 插件