Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Thorac Surg Clin. 2011 Feb;21(1):107-14, viii. doi: 10.1016/j.thorsurg.2010.08.003.
Although thymoma and thymic carcinoma are rare malignancies, they constitute a large proportion of tumors of the anterior mediastinum. Surgery forms the mainstay of therapy; however, thymic malignancies are sensitive to chemotherapy and radiation therapy also. Systemic chemotherapy is primarily used for treatment of metastatic or recurrent disease. Chemotherapy is also used as a component of multimodality treatment in the neoadjuvant setting with the aim of increasing the chances of achieving a complete surgical resection. In this article we outline various clinical trials that have been performed to evaluate the role of chemotherapy in the treatment of thymic malignancies.
虽然胸腺瘤和胸腺癌是罕见的恶性肿瘤，但它们在前纵隔肿瘤中占有很大比例。手术是主要的治疗方法；然而，胸腺癌对化疗和放疗也很敏感。全身化疗主要用于治疗转移性或复发性疾病。化疗也被用作新辅助治疗的多模式治疗的一部分，目的是增加实现完全手术切除的机会。本文概述了已进行的各种临床试验，以评估化疗在胸腺癌治疗中的作用。
