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多囊卵巢综合征和母体肥胖会影响体外受精/胞浆内单精子注射周期中的卵母细胞大小。

Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles.

机构信息

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63108, USA.

出版信息

Fertil Steril. 2011 May;95(6):2146-9, 2149.e1. doi: 10.1016/j.fertnstert.2010.10.026. Epub 2010 Nov 11.

DOI:10.1016/j.fertnstert.2010.10.026
PMID:21071018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3684964/
Abstract

To determine the impact of maternal metabolic state on oocyte development in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), we retrospectively analyzed a cohort of women with PCOS undergoing IVF/ICSI from 2008-2009 in a university-based fertility center. We determined that women with PCOS and obesity have smaller oocytes than control subjects, and that when further subdivided by body mass index, both PCOS and obesity independently influence oocyte size.

摘要

为了确定母体代谢状态对接受体外受精/胞浆内单精子注射（IVF/ICSI）的女性卵母细胞发育的影响，我们回顾性分析了 2008-2009 年在一家大学生育中心接受 IVF/ICSI 的多囊卵巢综合征（PCOS）女性的队列。我们发现，肥胖的 PCOS 女性的卵母细胞比对照组小，而当进一步按体重指数细分时，PCOS 和肥胖均独立影响卵母细胞大小。

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Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles.多囊卵巢综合征和母体肥胖会影响体外受精/胞浆内单精子注射周期中的卵母细胞大小。
Fertil Steril. 2011 May;95(6):2146-9, 2149.e1. doi: 10.1016/j.fertnstert.2010.10.026. Epub 2010 Nov 11.
2
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本文引用的文献

1
Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring.饮食诱导肥胖模型：卵母细胞异常和后代持续生长异常。
Endocrinology. 2010 Aug;151(8):4039-46. doi: 10.1210/en.2010-0098. Epub 2010 Jun 23.
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Fertility treatment in women with polycystic ovary syndrome: a decision analysis of different oral ovulation induction agents.多囊卵巢综合征女性的生育治疗：不同口服排卵诱导药物的决策分析。
Fertil Steril. 2010 Dec;94(7):2659-64. doi: 10.1016/j.fertnstert.2010.03.077. Epub 2010 May 7.
3
Oocyte diameter as a predictor of fertilization and embryo quality in assisted reproduction cycles.卵母细胞直径作为辅助生殖周期中受精和胚胎质量的预测指标。
Fertil Steril. 2010 Feb;93(2):621-5. doi: 10.1016/j.fertnstert.2008.12.124. Epub 2009 May 6.
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Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women.与体重适中的女性相比，肥胖女性在卵巢代谢物、激素和基因表达方面存在差异。
J Clin Endocrinol Metab. 2009 May;94(5):1533-40. doi: 10.1210/jc.2008-2648. Epub 2009 Feb 17.
5
Female obesity impairs in vitro fertilization outcome without affecting embryo quality.女性肥胖会损害体外受精的结果，但不影响胚胎质量。
Fertil Steril. 2010 Feb;93(2):447-54. doi: 10.1016/j.fertnstert.2008.12.032. Epub 2009 Jan 26.
6
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report.多囊卵巢综合征的雄激素过多与多囊卵巢综合征学会标准：特别工作组完整报告
Fertil Steril. 2009 Feb;91(2):456-88. doi: 10.1016/j.fertnstert.2008.06.035. Epub 2008 Oct 23.
7
Morbid obesity is associated with lower clinical pregnancy rates after in vitro fertilization in women with polycystic ovary syndrome.多囊卵巢综合征女性体外受精后，病态肥胖与较低的临床妊娠率相关。
Fertil Steril. 2009 Jul;92(1):256-61. doi: 10.1016/j.fertnstert.2008.04.063. Epub 2008 Aug 9.
8
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality.过氧化物酶体增殖物激活受体γ激动剂罗格列酮可逆转饮食诱导的肥胖对卵母细胞质量的不利影响。
Endocrinology. 2008 May;149(5):2646-56. doi: 10.1210/en.2007-1570. Epub 2008 Feb 14.
9
Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence.高体重指数会增加自然受孕和辅助受孕后流产的风险吗？证据的荟萃分析。
Fertil Steril. 2008 Sep;90(3):714-26. doi: 10.1016/j.fertnstert.2007.07.1290. Epub 2008 Feb 6.
10
One-cell zygote transfer from diabetic to nondiabetic mouse results in congenital malformations and growth retardation in offspring.将单细胞受精卵从糖尿病小鼠转移到非糖尿病小鼠体内，会导致后代出现先天性畸形和生长发育迟缓。
Endocrinology. 2008 Feb;149(2):466-9. doi: 10.1210/en.2007-1273. Epub 2007 Nov 26.