Department of Obstetrics and Gynecology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Fertil Steril. 2010 Feb;93(2):621-5. doi: 10.1016/j.fertnstert.2008.12.124. Epub 2009 May 6.
To assess the impact of the mean oocyte diameter (MOD) on occurrence of fertilization and embryo quality in assisted reproduction cycles.
Prospective observational study.
Sector of Human Reproduction of the University Hospital, Faculty of Medicine of Ribeirão Preto, University of São Paulo (HCFMRP-USP).
PATIENT(S): Thirty-five women undergoing intracytoplasmic sperm injection (ICSI) at the University Hospital of Ribeirão Preto from May to October 2007.
INTERVENTION(S): MOD assessment.
MAIN OUTCOME MEASURE(S): Occurrence of fertilization and qualitative embryo classification on 2nd and 3rd day after ICSI.
RESULT(S): We divided 160 metaphase II oocytes according to MOD into groups A (MOD below the 25th percentile), B (MOD between 25th and 75th percentile), and C (MOD above the 75th percentile). There was no statistically significant association between MOD and the occurrence of fertilization or the qualitative embryo classification on days 2 and 3. There was no statistically significant difference between groups regarding number of cells or the qualitative embryo classification on days 2 and 3.
CONCLUSION(S): The MOD of mature oocytes does not seem to be related to the occurrence of fertilization or to the developmental quality of human embryos on days 2 and 3 after ICSI.
评估平均卵母细胞直径（MOD）对辅助生殖周期中受精和胚胎质量发生的影响。
前瞻性观察研究。
圣保罗大学里贝朗普雷托医学院人类生殖科大学医院（HCFMRP-USP）。
2007 年 5 月至 10 月在里贝朗普雷托大学医院接受胞浆内单精子注射（ICSI）的 35 名妇女。
MOD 评估。
ICSI 后第 2 天和第 3 天受精发生和定性胚胎分类。
我们根据 MOD 将 160 个中期 II 卵母细胞分为 A 组（MOD 低于第 25 百分位）、B 组（MOD 在第 25 百分位至第 75 百分位之间）和 C 组（MOD 高于第 75 百分位）。MOD 与受精发生或 ICSI 后第 2 天和第 3 天定性胚胎分类之间无统计学显著相关性。第 2 天和第 3 天，各组之间的细胞数或定性胚胎分类无统计学显著差异。
成熟卵母细胞的 MOD 似乎与 ICSI 后第 2 天和第 3 天的受精发生或人类胚胎的发育质量无关。
