Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Invest Ophthalmol Vis Sci. 2011 Feb 16;52(2):927-32. doi: 10.1167/iovs.10-5664.
To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients.
MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline.
Forty-five eyes of 41 subjects, who had no ocular disorders or fundus autofluorescence abnormalities except for age-related nuclear cataract, were included. Preoperative MPOD was 0.350 ± 0.117 density unit (DU). Regression analysis showed that a higher nuclear color score correlated with lower MPOD (t = -2.90, P = 0.0063). The preoperative MPOD prediction formula was MPOD = 0.545 - 0.069 × nuclear color score. A higher nuclear color score correlated significantly with failure to measure the MPOD (χ(2) = 5.08, P = 0.0242). The mean postoperative MPOD was 0.600 DU (95% confidence interval [CI], 0.562-0.637), which was significantly (P < 0.0001) higher than the preoperative level of 0.350 DU (95% CI, 0.313-0.388). Regression analysis showed that higher preoperative MPOD correlated with higher postoperative MPOD (t = 2.91, P = 0.0061).
Cataract, especially its nuclear component, affects MPOD measured by autofluorescence spectrometry. Care should be taken when using this method in eyes with age-related macular maculopathy and age-related macular degeneration and in older patients who may develop these diseases.
评估白内障对老年患者黄斑色素光学密度(MPOD)评估的影响。
采用自发荧光光谱法在白内障手术前后对 MPOD 进行前瞻性测量。在基线时,使用 Lens Opacities Classification System III 对白内障进行分级。
共纳入 41 例患者的 45 只眼,除年龄相关性核性白内障外,这些患者无眼部疾病或眼底自发荧光异常。术前 MPOD 为 0.350 ± 0.117 密度单位(DU)。回归分析显示,较高的核色评分与较低的 MPOD 相关(t=-2.90,P=0.0063)。术前 MPOD 预测公式为 MPOD=0.545-0.069×核色评分。较高的核色评分与无法测量 MPOD 显著相关(χ²=5.08,P=0.0242)。平均术后 MPOD 为 0.600 DU(95%置信区间[CI],0.562-0.637),显著高于术前的 0.350 DU(95% CI,0.313-0.388)(P<0.0001)。回归分析显示,术前较高的 MPOD 与术后较高的 MPOD 相关(t=2.91,P=0.0061)。
白内障,尤其是其核成分,会影响自发荧光光谱法测量的 MPOD。在患有年龄相关性黄斑病变和年龄相关性黄斑变性以及可能患有这些疾病的老年患者中使用这种方法时应谨慎。