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大豆皂苷（来自大豆的肾素抑制剂）对自发性高血压大鼠血压的降低作用。

Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats.

作者信息

Hiwatashi Kazuyuki, Shirakawa Hitoshi, Hori Kazuyuki, Yoshiki Yumiko, Suzuki Nao, Hokari Mika, Komai Michio, Takahashi Saori

机构信息

Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.

出版信息

Biosci Biotechnol Biochem. 2010;74(11):2310-2. doi: 10.1271/bbb.100328. Epub 2010 Nov 7.

DOI:10.1271/bbb.100328
PMID:21071835
Abstract

The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC(50)=59.9 µg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

摘要

研究了市售纯化大豆皂苷对肾素活性和血压的影响。大豆皂苷在体外能显著抑制人肾素，半数抑制浓度（IC50）为59.9微克/毫升。每天以80毫克/千克体重的剂量给自发性高血压大鼠口服大豆皂苷，持续8周，可显著降低血压。

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