Department of Cardiology, National Hospital Organization Tokyo Medical Center, Meguro-ku, Tokyo, Japan.
J Atheroscler Thromb. 2011;18(2):108-14. doi: 10.5551/jat.6023. Epub 2010 Nov 6.
Resistin is an adipocytokine that may link inflammation and atherosclerosis.We studied the associations of resistin levels with cardiovascular events and restenosis.
We measured pre-procedural serum resistin levels in 140 patients with coronary artery disease undergoing elective percutaneous coronary intervention (PCI), of whom 97 had a stent. Restenosis was defined as > 50% stenosis at follow-up angiography. Patients were followed for 3 years for major adverse cardiovascular events (MACE).
At 8±6 months after PCI, reangiography was performed in 94 (67%) patients, of whom 42 had restenosis. Between 42 patients with restenosis and 52 without restenosis, resistin (4.5±2.6 vs. 4.5±2.5 ng/mL) and Creactive protein (CRP) (median 0.70 vs. 0.70 mg/L) levels did not differ. During 3-year follow-up, MACE occurred in 24 patients (1 death, 21 unstable angina, 2 stroke). Compared with 116 patients without MACE, 24 with MACE had higher resistin (5.4±2.4 vs. 4.3±2.5 ng/mL) and CRP (1.30 vs. 0.60 mg/L) levels (p< 0.05). Patients with MACE more often had resistin >4.0 ng/mL than without MACE (75% vs. 35%, p< 0.001). Resistin correlated with CRP levels (r= 0.31). To clarify the association between MACE and resistin, patients were divided into 2 groups by resistin levels. Kaplan-Meier analysis showed a lower event-free survival rate in patients with resistin > 4.0 ng/mL than without it (p< 0.001). On multivariate analysis, resistin, but not CRP, was an independent predictor of MACE. The hazard ratio for MACE was 3.6 (95%CI=1.4-9.2) for resistin > 4.0 ng/mL.
Serum resistin levels were found to be associated with further cardiovascular events in patients undergoing PCI.
抵抗素是一种脂肪细胞因子，可能与炎症和动脉粥样硬化有关。我们研究了抵抗素水平与心血管事件和再狭窄的关系。
我们测量了 140 名接受选择性经皮冠状动脉介入治疗（PCI）的冠心病患者术前血清抵抗素水平，其中 97 名患者植入了支架。再狭窄定义为随访血管造影时 > 50%的狭窄。患者接受了 3 年的主要不良心血管事件（MACE）随访。
PCI 后 8±6 个月，94 名（67%）患者进行了再次血管造影，其中 42 名发生了再狭窄。在 42 名再狭窄患者和 52 名无再狭窄患者中，抵抗素（4.5±2.6 与 4.5±2.5ng/ml）和 C 反应蛋白（CRP）（中位数 0.70 与 0.70mg/L）水平无差异。在 3 年的随访中，24 名患者发生了 MACE（1 例死亡，21 例不稳定型心绞痛，2 例卒中）。与 116 名无 MACE 的患者相比，24 名有 MACE 的患者的抵抗素（5.4±2.4 与 4.3±2.5ng/ml）和 CRP（1.30 与 0.60mg/L）水平更高（p<0.05）。有 MACE 的患者比无 MACE 的患者更常出现抵抗素>4.0ng/ml（75%比 35%，p<0.001）。抵抗素与 CRP 水平相关（r=0.31）。为了阐明 MACE 和抵抗素之间的关系，我们根据抵抗素水平将患者分为两组。Kaplan-Meier 分析显示，抵抗素>4.0ng/ml 的患者无事件生存率低于无抵抗素者（p<0.001）。多变量分析显示，抵抗素而不是 CRP 是 MACE 的独立预测因子。抵抗素>4.0ng/ml 时，MACE 的危险比为 3.6（95%CI=1.4-9.2）。
在接受 PCI 的患者中，血清抵抗素水平与进一步的心血管事件有关。
