Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.
J Atheroscler Thromb. 2010 Dec 26;17(12):1290-6. doi: 10.5551/jat.5389. Epub 2010 Nov 6.
The aim of this study was to investigate whether peripheral arterial disease (PAD) is predictive of disability and whether the relationship between PAD and disability can be fully explained by baseline physical functions.
We followed for five years 783 Japanese aged 70 years or older without a disability at baseline in 2003. We defined participants certificed as requiring long-term care as having incident disability. The hazard ratio (HR) and 95% confidence interval (95% CI) for incident disability were calculated using the Cox proportional hazards model.
After adjusting for possible confounders other than physical function, the HR of incident disability among participants with PAD was 1.86 (95%CI: 1.06 to 3.26).Although the risk was attenuated (HR=1.63, 95%CI: 0.92 to 2.86) after adding baseline physical function as a covariate, the HR was still high. Furthermore, the relation was not statistically significant, but the group with higher physical function and PAD also had a higher HR of incident disability than those who had higher physical function without PAD.
PAD is an important predictor of disability even if the level of baseline physical function is high.
本研究旨在探讨外周动脉疾病（PAD）是否可预测残疾，以及 PAD 与残疾之间的关系是否可以完全用基线身体功能来解释。
我们对 2003 年基线时无残疾的 783 名 70 岁或以上的日本老年人进行了为期五年的随访。我们将被认定为需要长期护理的参与者定义为发生残疾。使用 Cox 比例风险模型计算残疾发生的风险比（HR）和 95%置信区间（95%CI）。
在调整除身体功能以外的可能混杂因素后，PAD 患者残疾发生的 HR 为 1.86（95%CI：1.06 至 3.26）。尽管在加入基线身体功能作为协变量后，风险有所降低（HR=1.63，95%CI：0.92 至 2.86），但 HR 仍然较高。此外，这种关系没有统计学意义，但与没有 PAD 的高身体功能组相比，高身体功能和 PAD 组的残疾发生 HR 也更高。
即使基线身体功能水平较高，PAD 也是残疾的重要预测因素。
