Mori H, Hanabayashi T, Yamada Y, Tamaya T
Department of Obsetrics and Gynecology, Gifu University School of Medicine, Japan.
J Clin Immunol. 1990 Jan;10(1):45-51. doi: 10.1007/BF00917497.
The interferon-gamma (IFN-gamma) productivity of peripheral blood mononuclear cells (PBMCs) was examined in 30 patients with uterine cervical cancer. The patients under 50 years of age had decreased IFN-gamma production compared with the age-matched controls. The IFN-gamma productivity in the patients over 50 years of age was decreased as well as in the age-matched controls. The proportion of monocytes in PBMCs did not correlate with the IFN-gamma productivity. The prostaglandin E2 (PGE2) productivity of PBMCs increased with the progress of cancer. PGE2 inhibited the IFN-gamma production by PBMCs, and the sensitivity of PBMCs to PGE2 was increased in the patients and controls over 60 years of age. The addition of indomethacin resulted in an increase in IFN-gamma production by PBMCs. These results suggest that the increased production of PGE2 and/or increased sensitivity to PGE2 are responsible for the decreased IFN-gamma production in patients with cervical cancer.
检测了30例子宫颈癌患者外周血单个核细胞（PBMCs）的干扰素-γ（IFN-γ）产生能力。50岁以下的患者与年龄匹配的对照组相比，IFN-γ产生减少。50岁以上患者的IFN-γ产生能力以及年龄匹配的对照组均降低。PBMCs中单核细胞的比例与IFN-γ产生能力无关。PBMCs的前列腺素E2（PGE2）产生能力随癌症进展而增加。PGE2抑制PBMCs产生IFN-γ，60岁以上的患者和对照组中PBMCs对PGE2的敏感性增加。添加吲哚美辛导致PBMCs产生IFN-γ增加。这些结果表明，PGE2产生增加和/或对PGE2敏感性增加是宫颈癌患者IFN-γ产生减少的原因。
