The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA.
Cancer Causes Control. 2011 Jan;22(1):73-9. doi: 10.1007/s10552-010-9676-5. Epub 2010 Nov 12.
The International Lung Cancer Consortium (ILCCO) was established in 2004, based on the collaboration of research groups leading large molecular epidemiology studies of lung cancer that are ongoing or have been recently completed. This framework offered the opportunity to investigate the role of tobacco smoking in the development of bronchioloalveolar carcinoma (BAC), a rare form of lung cancer.
Our pooled data comprised seven case-control studies from the United States, with detailed information on tobacco smoking and histology, which contributed 799 cases of BAC and 15,859 controls. We estimated the odds ratio of BAC for tobacco smoking, using never smokers as a referent category, after adjustment for age, sex, race, and study center.
The odds ratio of BAC for ever smoking was 2.47 (95% confidence interval [CI] 2.08, 2.93); the risk increased linearly with duration, amount, and cumulative cigarette smoking and persisted long after smoking cessation. The proportion of BAC cases attributable to smoking was 0.47 (95% CI 0.39, 0.54).
This analysis provides a precise estimate of the risk of BAC for tobacco smoking.
国际肺癌联合会（ILCCO）成立于 2004 年，是基于正在进行或最近完成的大型肺癌分子流行病学研究的研究小组合作建立的。这一框架提供了研究吸烟在细支气管肺泡癌（BAC）发展中的作用的机会，BAC 是一种罕见的肺癌形式。
我们的汇总数据包括来自美国的 7 项病例对照研究，这些研究提供了关于吸烟和组织学的详细信息，为 799 例 BAC 病例和 15859 例对照提供了信息。我们在调整年龄、性别、种族和研究中心后，以从不吸烟者为参照类别，估计了 BAC 与吸烟之间的比值比。
吸烟与 BAC 的比值比为 2.47（95%置信区间[CI]为 2.08，2.93）；风险随着吸烟时间、吸烟量和累计吸烟量的增加而线性增加，并且在戒烟后很长时间内仍然存在。归因于吸烟的 BAC 病例比例为 0.47（95%CI 为 0.39，0.54）。
这项分析提供了吸烟导致 BAC 的风险的精确估计。
