Morabia A, Wynder E L
American Health Foundation, New York, NY 10017.
BMJ. 1992 Feb 29;304(6826):541-3. doi: 10.1136/bmj.304.6826.541.
To determine whether bronchioalveolar carcinoma is related to tobacco use.
Case-control study.
11 teaching hospitals of Chicago, Long Island, New York, and Philadelphia, 1977-89.
87 patients with histologically diagnosed bronchioloalveolar carcinoma (cases) and 286 non-cancer and 297 cancer patients matched to cases on age, sex, race, hospital, and date of admission.
10% of male cases and 25% of female cases had never smoked. Relative risks of bronchioloalveolar carcinoma (as estimated by the relative odds) were greater for subjects who started smoking at a younger age, smoked for a longer time, or smoked more cigarettes per day. Relative risks decreased proportionally to the duration of smoking cessation.
Smoking plays an important part in the aetiology of bronchioloalveolar carcinoma but is not the only potential cause because of the large proportion of never smokers among patients with this disease.
确定细支气管肺泡癌是否与吸烟有关。
病例对照研究。
1977 - 1989年期间，位于芝加哥、纽约长岛和费城的11家教学医院。
87例经组织学诊断为细支气管肺泡癌的患者（病例组），以及286例非癌症患者和297例癌症患者，这些对照在年龄、性别、种族、医院和入院日期方面与病例组相匹配。
10%的男性病例和25%的女性病例从不吸烟。开始吸烟年龄较小、吸烟时间较长或每天吸烟量较多的受试者，患细支气管肺泡癌的相对风险（通过相对比值估计）更高。相对风险与戒烟持续时间成比例下降。
吸烟在细支气管肺泡癌的病因中起重要作用，但不是唯一的潜在病因，因为该病患者中有很大比例从不吸烟。
