Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.
Pediatr Blood Cancer. 2011 Mar;56(3):477-81. doi: 10.1002/pbc.22615.
Data pertaining to outcomes in jaw primitive neuroectodermal tumor (PNET) are lacking. Eleven cases of jaw PNET (five maxillary and six mandibular) were treated at our cancer center with the same chemotherapeutic agents from June 2003 to January 2009. Four patients underwent surgery after neoadjuvant chemotherapy and all received local radiotherapy. At median follow-up of 56 months (range: 19-77 months), 7/11 patients are in sustained remission. There was no difference in outcome with respect to site of tumor, and whether surgery was performed or not. These results support the use of chemoradiation as initial modality of treatment rather than going for extensive and mutilating surgery.
关于颌骨原始神经外胚层肿瘤（PNET）的结局数据尚缺乏。2003 年 6 月至 2009 年 1 月，我们癌症中心采用相同的化疗药物治疗了 11 例颌骨 PNET（5 例上颌骨，6 例下颌骨）。4 例患者在新辅助化疗后接受了手术，所有患者均接受了局部放疗。中位随访时间为 56 个月（范围：19-77 个月），11 例患者中有 7 例持续缓解。肿瘤部位、是否进行手术与结局均无差异。这些结果支持将放化疗作为初始治疗方式，而不是进行广泛且破坏性的手术。
