Giday Araya, Shiferaw Wogen
Hawassa University, Collage of Medicine, Hawassa ,Ethiopia.
Ethiop Med J. 2010 Jul;48(3):187-94.
Higher level of antiretroviral adherence is associated with improved virological, immunological and clinical outcomes. Despite the availability of few studies in sub Saharan Africa the factors for poor adherence are diverse.
To determine adherence factors for antiretroviral treatment in Hawassa University teaching hospital in southern Ethiopia.
A cross sectional study was undertaken on total of 510 AIDS patients seen over one month period Data were collected using a structured questionnaire and analysis was done using SPSS 15.0.
Out of interviewed patients 88.2% of them had > or = 95% and 97.1% of them had > or =80% antiretroviral adherence rate by self report over one month period. The major reasons for missing drugs in 79.8% were forgetting to take drug, gastrointestinal symptoms, give priority for praying, being hopeless and inadequate adherence counseling Significant predictors of poor adherence were lower level of knowledge about adherence, absence of job and 'Sidamnigna' as primary language. It is also observed that trend of adherence decreased as level of education decrease.
Adherence rate found in this study is higher than many developed and developing countries and equivalent to other studies done in Ethiopia. Those who speak local language, jobless and having low education level may require intensive counseling to optimize their adherence.
更高水平的抗逆转录病毒治疗依从性与改善病毒学、免疫学和临床结局相关。尽管撒哈拉以南非洲地区的相关研究较少，但依从性差的因素多种多样。
确定埃塞俄比亚南部哈瓦萨大学教学医院抗逆转录病毒治疗的依从性因素。
对在一个月期间就诊的510名艾滋病患者进行了横断面研究。使用结构化问卷收集数据，并使用SPSS 15.0进行分析。
在接受访谈的患者中，88.2%的患者在一个月期间自我报告的抗逆转录病毒治疗依从率≥95%，97.1%的患者≥80%。79.8%的患者漏服药物的主要原因是忘记服药、胃肠道症状、优先祈祷、绝望以及依从性咨询不足。依从性差的显著预测因素是对依从性的了解程度较低、没有工作以及以“西达摩尼加语”作为主要语言。还观察到依从性趋势随着教育水平的降低而下降。
本研究中发现的依从率高于许多发达国家和发展中国家，与在埃塞俄比亚进行的其他研究相当。那些说当地语言、没有工作且教育水平较低的人可能需要强化咨询以优化其依从性。
