笼状二聚体中仅用两条 DNA 双链的协同熔化。
Cooperative melting in caged dimers with only two DNA duplexes.
机构信息
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
出版信息
J Am Chem Soc. 2010 Dec 8;132(48):17068-70. doi: 10.1021/ja107232x. Epub 2010 Nov 12.
Abstract
Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.
摘要
仅含有两条平行 DNA 双链的小分子-DNA 杂交物（rSMDH2）与未经修饰的 DNA 双链相比，具有更陡峭的熔解曲线，这与相邻双链理论的预测一致。使用粗粒动力学模拟得到的调整热力学参数，实验数据很好地符合分析模型。
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