Department of Pharmacology, Simmons Comprehensive Cancer Center , UT Southwestern Medical Center , 5323 Harry Hines Boulevard , Dallas , Texas 75390 , United States.
Beijing Key Laboratory of Molecular Pharmaceutics and State Key Laboratory of Natural and Biomimetic Drugs , Peking University , Beijing , 100191 , China.
Chem Rev. 2018 Jun 13;118(11):5359-5391. doi: 10.1021/acs.chemrev.8b00195. Epub 2018 Apr 25.
Nanomedicine is a discipline that applies nanoscience and nanotechnology principles to the prevention, diagnosis, and treatment of human diseases. Self-assembly of molecular components is becoming a common strategy in the design and syntheses of nanomaterials for biomedical applications. In both natural and synthetic self-assembled nanostructures, molecular cooperativity is emerging as an important hallmark. In many cases, interplay of many types of noncovalent interactions leads to dynamic nanosystems with emergent properties where the whole is bigger than the sum of the parts. In this review, we provide a comprehensive analysis of the cooperativity principles in multiple self-assembled nanostructures. We discuss the molecular origin and quantitative modeling of cooperative behaviors. In selected systems, we describe the examples on how to leverage molecular cooperativity to design nanomedicine with improved diagnostic precision and therapeutic efficacy in medicine.
纳米医学是一门将纳米科学和纳米技术原理应用于人类疾病的预防、诊断和治疗的学科。分子组件的自组装正成为设计和合成用于生物医学应用的纳米材料的常用策略。在天然和合成的自组装纳米结构中，分子协同作用正成为一个重要的标志。在许多情况下，多种非共价相互作用的相互作用导致具有新兴特性的动态纳米系统，其中整体大于部分的总和。在这篇综述中，我们对多种自组装纳米结构中的协同作用原理进行了全面分析。我们讨论了协同行为的分子起源和定量建模。在选定的系统中，我们描述了如何利用分子协同作用来设计具有改进的诊断精度和治疗效果的纳米医学的例子。
