Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Future Microbiol. 2010 Oct;5(10):1483-92. doi: 10.2217/fmb.10.108.
Mounting evidence supports the intuitive idea that many of the factors produced in defense of the epithelial surface, including mucin and secretory IgA, promote the growth of the commensal microbial flora, much the same as plant-derived mucoid substances support the growth of symbiotic microbes in the rhizosphere associated with roots. Thus, the 'defense' of the host epithelial surface often involves support and maintenance of microbial growth, despite an unfortunate tendency to view the immune system as an antagonist to the microbial flora. The perspective that the immune system supports the growth of a symbiotic microbiota has the potential to push forward our understanding of host-microbe interactions and to facilitate the development of new treatments for diseases associated with the microbiota.
越来越多的证据支持这样一种直观的观点，即上皮表面产生的许多防御因子，包括粘蛋白和分泌型 IgA，促进了共生微生物菌群的生长，就像植物来源的粘质物质支持与根系相关的根际共生微生物的生长一样。因此，尽管人们常常将免疫系统视为微生物菌群的拮抗剂，但宿主上皮表面的“防御”通常涉及支持和维持微生物的生长。免疫系统支持共生微生物菌群生长的观点有可能推动我们对宿主-微生物相互作用的理解，并促进开发与微生物群相关疾病的新治疗方法。
