Anderson Kelsi L, Dunman Paul M
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-6495, USA.
Int J Microbiol. 2009;2009:525491. doi: 10.1155/2009/525491. Epub 2009 Mar 5.
The regulation of mRNA turnover is a recently appreciated phenomenon by which bacteria modulate gene expression. This review outlines the mechanisms by which three major classes of bacterial trans-acting factors, ribonucleases (RNases), RNA binding proteins, and small noncoding RNAs (sRNA), regulate the transcript stability and protein production of target genes. Because the mechanisms of RNA decay and maturation are best characterized in Escherichia coli, the majority of this review will focus on how these factors modulate mRNA stability in this organism. However, we also address the effects of RNases, RNA binding proteins, sRNAs on mRNA turnover, and gene expression in Bacillus subtilis, which has served as a model for studying RNA processing in gram-positive organisms. We conclude by discussing emerging studies on the role modulating mRNA stability has on gene expression in the important human pathogen Staphylococcus aureus.
mRNA周转的调控是细菌调节基因表达的一种最近才被认识到的现象。本综述概述了三类主要的细菌反式作用因子，即核糖核酸酶（RNase）、RNA结合蛋白和小非编码RNA（sRNA），调节靶基因转录本稳定性和蛋白质产生的机制。由于RNA衰变和成熟机制在大肠杆菌中得到了最充分的表征，因此本综述的大部分内容将聚焦于这些因子如何在该生物体中调节mRNA稳定性。然而，我们也讨论了RNase、RNA结合蛋白、sRNA对枯草芽孢杆菌mRNA周转和基因表达的影响，枯草芽孢杆菌一直是研究革兰氏阳性菌中RNA加工的模型。我们通过讨论关于调节mRNA稳定性在重要人类病原体金黄色葡萄球菌基因表达中的作用的新兴研究来结束本文。
