Department of Family Medicine, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.
Scand J Clin Lab Invest. 2011 Feb;71(1):1-6. doi: 10.3109/00365513.2010.519047. Epub 2010 Nov 15.
The features of the metabolic syndrome include glucose intolerance, hypertension, dyslipidemia, and central obesity, all of which are risk factors for diabetes and cardiovascular disease. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) play a key role in atherosclerosis. We examined the association between chemokines, such as MCP-1 and IL-8, and metabolic syndrome.
The present study was comprised of 54 men and 126 women. Subjects with cardiovascular disease such as myocardial infarction, TIA and cerebral infarction were excluded.
MCP-1 was positively correlated with homeostasis model assessment of insulin resistance, homocysteine, and mean pulse wave velocity, but IL-8 was not. In multiple regression analysis, age, HOMA-IR and homocysteine were found to be an independent factor associated with MCP-1 adjusted by gender, waist, systolic blood pressure, triglyceride, HDL-cholesterol, and hs-CRP. After adjustment for age and gender, mean MCP-1 was higher in subjects with metabolic syndrome and in subject with high blood pressure among the individual components of the metabolic syndrome.
MCP-1 was associated with a low-grade systemic inflammatory reaction which is often found in the metabolic syndrome.
代谢综合征的特征包括葡萄糖耐量异常、高血压、血脂异常和中心性肥胖，所有这些都是糖尿病和心血管疾病的危险因素。单核细胞趋化蛋白-1（MCP-1）和白细胞介素-8（IL-8）在动脉粥样硬化中起关键作用。我们研究了趋化因子（如 MCP-1 和 IL-8）与代谢综合征之间的关系。
本研究共纳入 54 名男性和 126 名女性。排除了患有心肌梗死、TIA 和脑梗死等心血管疾病的患者。
MCP-1 与稳态模型评估的胰岛素抵抗、同型半胱氨酸和平均脉搏波速度呈正相关，而 IL-8 则没有。在多元回归分析中，发现年龄、HOMA-IR 和同型半胱氨酸是与性别、腰围、收缩压、甘油三酯、HDL-胆固醇和 hs-CRP 校正后的 MCP-1 相关的独立因素。在调整年龄和性别后，代谢综合征患者和代谢综合征中高血压患者的平均 MCP-1 较高。
MCP-1 与代谢综合征中常见的低度全身炎症反应有关。
