School of Medicine, Najing University, Nanjing, Jiangsu, PR China.
Fitoterapia. 2011 Apr;82(3):323-30. doi: 10.1016/j.fitote.2010.11.007. Epub 2010 Nov 10.
Berberine was reported to protect against the intestinal injury and improve the survival rate in sepsis, and glutamine deficiency was considered to be correlated with mortality in sepsis. We found that berberine pretreatment ameliorated lipopolysaccharide-induced direct intestinal injury and mucosal hypoplasia and attenuated impairments of intestinal glutamine transport and glutaminase activity, B(0)AT1 mRNA and protein expressions, and glutaminase protein expression. These findings showed the first time that berberine pretreatment could improve intestinal recovery and attenuate the impairment of glutamine transport and glutaminase activity in rat sepsis. This might be one of the mechanisms for the beneficial effect of berberine on sepsis.
小檗碱可预防脓毒症的肠道损伤和提高存活率，而谷氨酰胺缺乏与脓毒症的死亡率相关。我们发现小檗碱预处理可改善内毒素诱导的直接肠道损伤和黏膜发育不良，并减轻肠道谷氨酰胺转运和谷氨酰胺酶活性、B(0)AT1mRNA 和蛋白表达以及谷氨酰胺酶蛋白表达的损伤。这些发现首次表明，小檗碱预处理可改善脓毒症大鼠的肠道恢复，并减轻谷氨酰胺转运和谷氨酰胺酶活性的损伤。这可能是小檗碱对脓毒症有益作用的机制之一。
